Рис. F 2 seq
Нуклеотидная и аминокислотная последовательности
гена протромбина человека
aattcctcagtgacccaggagctgacacact
atg gcg cac gtc cga ggc ttg cag ctg cct ggc tgc ctg gcc ctg
met ala his val arg gly leu gln leu pro gly cys leu ala leu 15
gct gcc ctg tgt agc ctt gtg cac agc cag cat gtg ttc ctg gct
ala ala leu cys ser leu val his ser gln his val phe leu ala 30
cct cag caa gca cgg tcg ctg ctc cag cgg gtc cgg cga gcc aac
pro gln gln ala arg ser leu leu gln arg val arg arg ala asn 45
acc ttc ttg gag gag gtg cgc aag ggc aac cta gag cga gag tgc
thr phe leu glu glu val arg lys gly asn leu glu arg glu cys 60
gtg gag gag acg tgc agc tac gag gag gcc ttc gag gct ctg gag
val glu glu thr cys ser tyr glu glu ala phe glu ala leu glu 75
tcc tcc acg gct acg gat gtg ttc tgg gcc aag tac aca gct tgt
ser ser thr ala thr asp val phe trp ala lys tyr thr ala cys 90
gag aca gcg agg acg cct cga gat aag ctt gct gca tgt ctg gaa
glu thr ala arg thr pro arg asp lys leu ala ala cys leu glu 105
ggt aac tgt gct gag ggt ctg ggt acg aac tac cga ggg cat gtg
gly asn cys ala glu gly leu gly thr asn tyr arg gly his val 120
aac atc acc cgg tca ggc att gag tgc cag cta tgg agg agt cgc
asn ile thr arg ser gly ile glu cys gln leu trp arg ser arg 135
tac cca cat aag cct gaa atc aac tcc act acc cat cct ggg gcc
tyr pro his lys pro glu ile asn ser thr thr his pro gly ala 150
gac cta cag gag aat ttc tgc cgc aac ccc gac agc agc acc acg
asp leu gln glu asn phe cys arg asn pro asp ser ser thr thr 165
gga ccc tgg tgc tac act aca gac ccc acc gtg agg agg cag gaa
gly pro trp cys tyr thr thr asp pro thr val arg arg gln glu 180
tgc agc atc cct gtc tgt ggc cag gat caa gtc act gta gcg atg
cys ser ile pro val cys gly gln asp gln val thr val ala met 195
act cca cgc tcc gaa ggc tcc agt gtg aat ctg tca cct cca ttg
thr pro arg ser glu gly ser ser val asn leu ser pro pro leu 210
gag cag tgt gtc cct gat cgg ggg cag cag tac cag ggg cgc ctg
glu gln cys val pro asp arg gly gln gln tyr gln gly arg leu 225
gcg gtg acc aca cat ggg ctc ccc tgc ctg gcc tgg gcc agc gca
ala val thr thr his gly leu pro cys leu ala trp ala ser ala 240
cag gcc aag gcc ctg agc aag cac cag gac ttc aac tca gct gtg
gln ala lys ala leu ser lys his gln asp phe asn ser ala val 255
cag ctg gtg gag aac ttc tgc cgc aac cca gac ggg gat gag gag
gln leu val glu asn phe cys arg asn pro asp gly asp glu glu 270
ggc gtg tgg tgc tat gtg gcc ggg aag cct ggc gac ttt ggg tac
gly val trp cys tyr val ala gly lys pro gly asp phe gly tyr 285
tgc gac ctc aac tat tgt gag gag gcc gtg gag gag gag aca gga
cys asp leu asn tyr cys glu glu ala val glu glu glu thr gly 300
gat ggg ctg gat gag gac tca gac agg gcc atc gaa ggg cgt acc
asp glu leu asp glu asp ser asp arg ala ile glu gly arg thr 315
gcc acc agt gag tac cag act ttc ttc aat ccg agg acc ttt ggc
ala thr ser glu tyr gln thr phe phe asn pro arg thr phe gly 330
tcg gga gag gca gac tgt ggg ctg cga cct ctg ttc gag aag aag
ser gly glu ala asp cys gly leu arg pro leu phe glu lys lys 345
tcg ctg gag gac aaa acc gaa aga gag ctc ctg gaa tcc tac atc
ser leu glu asp lys thr glu arg glu leu leu glu ser tyr ile 360
gac ggg cgc att gtg gag ggc tcg gat gca gag atc ggc atg tca
asp gly arg ile val glu gly ser asp ala glu ile gly met ser 375
cct tgg cag gtg atg ctt ttc cgg aag agt ccc cag gag ctg ctg
pro trp gln val met leu phe arg lys ser pro gln glu leu leu 390
tgt ggg gcc agc ctc atc agt gac cgc tgg gtc ctc acc gcc gcc
cys gly ala ser leu ile ser asp arg trp val leu thr ala ala 405
cac tgc ctc ctg tac ccg ccc tgg gac aag aac ttc acc gag aat
his cys leu leu tyr pro pro trp asp lys asn phe thr glu asn 420
gac ctt ctg gtg cgc att ggc aag cac tcc cgc aca agg tac gag
asp leu leu val arg ile gly lys his ser arg thr arg tyr glu 435
cga aac att gaa aag ata tcc atg ttg gaa aag atc tac atc cac
arg asn ile glu lys ile ser met leu glu lys ile tyr ile his 450
ccc agg tac aac tgg cgg gag aac ctg gac cgg gac att gcc ctg
pro arg tyr asn trp arg glu asn leu asp arg asp ile ala leu 465
atg aag ctg aag aag cct gtt gcc ttc agt gac tac att cac cct
met lys leu lys lys pro val ala phe ser asp tyr ile his pro 480
gtg tgt ctg ccc gac agg gag acg gca gcc agc ttg ctc cag gct
val cys leu pro asp arg glu thr ala ala ser leu leu gln ala 495
gga tac aag ggg cgg gtg aca ggc tgg ggc aac ctg aag gag acg
gly tyr lys gly arg val thr gly trp gly asn leu lys glu thr 510
tgg aca gcc aac gtt ggt aag ggg cag ccc agt gtc ctg cag gtg
trp thr ala asn val gly lys gly gln pro ser val leu gln val 525
gtg aac ctg ccc att gtg gag cgg ccg gtc tgc aag gac tcc acc
val asn leu pro ile val glu arg pro val cys lys asp ser thr 540
cgg atc cgc atc act gac aac atg ttc tgt gct ggt tac aag cct
arg ile arg ile thr asp asn met phe cys ala gly tyr lys pro 555
gat gaa ggg aaa cga ggg gat gcc tgt gaa ggt gac agt ggg gga
asp glu gly lys arg gly asp ala cys glu gly asp ser gly gly 570
ccc ttt gtc atg aag agc ccc ttt aac aac cgc tgg tat caa atg
pro phe val met lys ser pro phe asn asn arg trp tyr gln met 595
ggc atc gtc tca tgg ggt gaa ggc tgt gac cgg gat ggg aaa tat
gly leu val ser trp gly glu gly cys asp arg asp gly lys tyr 610
ggc ttc tac aca cat gtg ttc cgc ctg aag aag tgg ata cag aag
gly phe tyr thr his val phe aef leu lys lys trp ile gln lys 625
gtc att gat cag ttt gga gag tag gggccactcatattctgggctcctgga
val ile asp gln phe gly glu ter
accaatcccgtgaaagaattatttttgtgtttctaaaactatggttcccaataaaagtg
actc tcagcgg
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