How Cells Protect Themselves against Stress?


T. M. Khlebodarova Institute of Cytology and Genetics. Russian Academy of Sciences. Novosibirsk, 630090 Russia; e-mail: tamara@bionet.nsc.ru The current evidence on the mechanisms underlying cell response to heat shock is reviewed. The response dynamics, induction, and attenuation as well as heat shock proteins and the mechanisms through which they protect cells from stress are considered. The role of these proteins in regulating the signaling cascades, including apoptosis suppression, is shown.571.6. Ingolia *., Craig E., McCarthy B. Sequence of three copies of the gene for the maior Drosophila heat shock186. Schaif K.D.. Rose S.. Zott W. et al. Three tomatto genes code for heat stress transcription factors with a region of remarkable homoloay to the DNA-bindina domain of - the yeast HSF // EMBO J. 1990. V. 9. P. 4495-4501.55. Usheva A., Maldonado E., Goldring A. et al. Specific interaction between the nonphosphorylated form of23. Rasmussen E.B.: Lis J.T. Short transcripts of the ternary complex provide insight into RNA polymerase II elongation pausing // J. Mol. Biol. 1995. V. 252. P. 525-535.

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