Рис. Col IV AIII seq
Нуклеотидная и аминокислотная последовательности гена коллагена IV типа альфа III (COL IV AIII) человека ATG AGC GCC CGG ACC GCC CCC AGG CCG CAG GTG CTC CTG CTG CCG met ser ala arg thr ala pro arg pro gln val leu leu leu pro 15 CTC CTG CTG GTG CTC CTG GCG GCG GCG CCC GCA GCC AGC AAG GGT leu leu leu val leu leu ala ala ala pro ala ala ser lys gly 30 TGT GTC TGT AAA GAC AAA GGC CAG TGC TTC TGT GAC GGG GCC AAA cys val cys lys asp lys gly gln cys phe cys asp gly ala lys 45 GGG GAG AAG GGG GAG AAG GGC TTT CCT GGA CCC CCC GGT TCT CCT gly glu lys gly glu lys gly phe pro gly pro pro gly ser pro 60 GGC CAG AAA GGA TTC ACA GGT CCT GAA GGC TTG ACT GGA CCG CAG gly gln lys gly phe thr gly pro glu gly leu thr gly pro gln 75 GGA CCC AAG GGC TTT CCA GGA CTT CCA GGA CTC ACG GGT TCC AAA gly pro lys gly phe pro gly leu pro gly leu thr gly ser lys 90 GGT GTA AGG GGA ATA AGT GGA TTG CCA GGA TTT TCT GGT TCT CCT gly val srg gly ile ser gly leu pro gly phe ser gly ser pro 105 GGA CTT CCA GGC ACC CCA GGC AAT ACC GGG CCT TAC GGA CTT GTC gly leu pro gly thr pro gly asn thr gly pro tyr gly leu val 120 GGT GTA CCA GGA TGC AGT GGT TCT AAG GGT GAG CAG GGG TTT CCA gly val pro gly cys ser gly ser lys gly glu gln gly phe pro 135 GGA CTC CCA GGG ACA CTG GGC TAC CCA GGG ATC CCG GGT GCT GCT gly leu pro gly thr leu gly tyr pro gly ile pro gly ala ala 150 GGT TTG AAA GGA CAA AAG GGT GCT CCT GCT AAA GAA GAA GAT ATA gly leu lys gly gln lys gly ala pro ala lys glu glu asp ile 165 GAA CTT GAT GCA AAA GGC GAC CCC GGG TTG CCA GGG GCT CCA GGA glu pro asp ala lys gly asp pro gly leu pro gly ala pro gly 180 CCC CAG GGT TTG CCA GGC CCT CCA GGT TTT CCT GGG CCT GTT GGC pro gln gly leu pro gly pro pro gly phe pro gly pro val gly 195 CCA CCT GGT CCT CCG GGA TTC TTT GGC TTT CCA GGA GCC ATG GGA pro pro gly pro pro gly phe phe gly phe pro gly ala met gly 210 CCT AGA GGA CCT AAG GGT CAC ATG GGT GAA AGA GTG ATA GGA CAT pro arg gly pro lys gly his met gly glu arg val ile gly his 225 AAA GGA GAG CGG GGT GTG AAA GGG TTA ACA GGA CCC CCG GGA CCA lys gly glu arg gly val lys gly leu thr gly pro pro gly pro 240 CCA GGA ACA GTT ATT GTG ACC CTA ACT GGC CCA GAT AAC AGA ACG pro gly thr val ile val thr leu thr gly pro asp asn arg thr 255 GAC CTC AAG GGG GAA AAG GGA GAC AAG GGA GCA ATG GGC GAG CCT asp leu lys gly glu lys gly asp lys gly ala met gly glu pro 270 GGA CCT CCT GGA CCC TCA GGA CTG CCT GGA GAA TCA TAT GGA TCT gly pro pro ala pro ser gly leu pro gly glu ser tyr gly ser 285 GAA AAG GGT GCT CCT GGA GAC CCT GGC CTG CAG GGA AAA CCC GGA glu lys gly ala pro gly asp pro gly leu gln gly lys pro gly 300 AAA GAT GGT GTT CCT GGC TTC CCT GGA AGT GAG GGA GTC AAG GGC lys asp gly val pro gly phe pro gly ser glu gly val lys gly 315 AAC AGG GGT TTC CCT GGG TTA ATG GGT GAA GAT GGC ATT AAG GGA asn arg gly phe pro gly leu met gly glu asp gly ile lys gly 330 CAG AAA GGG GAC ATT GGC CCT CCA GGA TTT CGT GGT CCA ACA GAA gln lys gly asp ile gly pro pro gly phe arg gly pro thr glu 345 TAT TAT GAC ACA TAC CAG GAA AAG GGA GAT GAA GGC ACT CCA GGC tyr tyr asp thr tyr gln glu lys gly asp glu gly thr pro gly 360 CCA CCA GGG CCC AGA GGA GCT CGT GGC CCA CAA GGT CCC AGT GGT pro pro gly pro arg gly ala arg gly pro gln gly pro ser gly 375 CCC CCC GGA GTT CCT GGA AGT CCT GGA TCA TCA AGG CCT GGC CTC pro pro gly val pro gly ser pro gly ser ser arg pro gly leu 390 AGA GGA GCC CCT GGA TGG CCA GGC TTG ATA GGA AGT AAA GGG GAA arg gly ala pro gly trp pro gly leu ile gly ser lys gly glu 405 CGA GGC CGC CCA GGA AAG GAT GCC ATG GGG ACT CCT GGG TCC CCA arg gly arg pro gly lys asp ala met gly thr pro gly ser pro 420 GGT TGT GCT GGT TCA CCA GGT CTT CCA GGA TCA CCG GGA CCT CCA gly cys ala gly ser pro gly leu pro gly ser pro gly pro pro 435 GGA CCG CCA GGT GAC ATC GGT TTT CGC AAG GGT CCA CCT GGA GAT gly pro pro gly asp ile gly phe arg lys gly pro pro gly asp 450 CAC GGA CTG CCA GGC TAT CTA GGG TCT CCA GGA ATC CCA GGA GTT his gly leu pro gly tyr leu gly ser pro gly ile pro gly val 465 GAT GGG CCC AAA GGA GAA CCA GGC CTC CTG TGT ACA CAG TGC CCT asp gly pro lys gly glu pro gly leu leu cys thr gln cys pro 480 TAT ATC CCA GGG CCT CCC GGT CTC CCA GGA TTG CCA GGG TTA CAT tyr ile pro gly pro pro gly leu pro gly leu pro gly leu his 495 GGT GTA AAA GGA ATC CCA GGA AGA CAA GGC GCA GCT GGC TTG AAA gly val lys gly ile pro gly arg gln gly ala ala gly leu lys 510 GGA AGC CCA GGG TCC CCA GGA AAT ACA GGT CTT CCA GGA TTT CCA gly ser pro gly ser pro gly asn thr gly leu pro gly phe pro 525 GGT TTC CCA GGT GCC CAG GGT GAC CCA GGA CTT AAA GGA GAA AAA gly phe pro gly ala gln gly asp pro gly leu lys gly glu lys 540 GGT GAA ACA CTT CAG CCT GAG GGG CAA GTG GGT GTC CCA GGT GAC gly glu thr leu gln pro glu gly gln val gly val pro gly asp 555 CCG GGG CTC AGA GGC CAA CCT GGG AGA AAG GGC TTG GAT GGA ATT pro gly leu arg gly gln pro gly arg lys gly leu asp gly ile 570 CCT GGA ACT CCG GGA GTG AAA GGA TTA CCA GGA CCT AAA GGC GAA pro gly thr pro gly val lys gly leu pro gly pro lys gly glu 585 CTG GCT CTG AGT GGT GAG AAA GGG GAC CAA GGT CCT CCA GGG GAT leu ala leu ser gly glu lys gly asp gln gly pro pro gly asp 600 CCT GGC TCC CCT GGG TCC CCA GGA CCT GCA GGA CCA GCT GGA CCA pro gly ser pro gly ser pro gly pro ala gly pro ala gly pro 615 CCT GGC TAC GGA CCC CAA GGA GAA CCT GGT CTC CAG GGC ACG CAA pro gly tyr gly pro gln gly glu pro gly leu gln gly thr gln 630 GGA GTT CCT GGG GCC CCC GGA CCA CCC GGA GAA GCC GGC CCT AGG gly val pro gly ala pro gly pro pro gly glu ala gly pro arg 645 GGA GAG CTC AGT GTT TCA ACA CCA GTT CCA GGC CCT CCA GGA CCT glu glu leu ser val ser thr pro val pro gly pro pro gly pro 660 CCA GGG CCC CCT GGC CAT CCT GGC CCC CAA GGT CCA CCT GGT ATC pro gly pro pro gly his pro gly pro gln gly pro pro gly ile 675 CCT GGA TCC CTG GGG AAA TGT GGA GAT CCT GGT CTT CCA GGG CCT pro gly ser leu gly lys cys gly asp pro gly leu pro gly pro 690 GAT GGT GAA CCA GGA ATT CCA GGA ATT GGA TTT CCT GGG CCA CCT asp gly glu pro gly ile pro gly ile gly phe pro gly pro pro 705 GGA CCT AAG GGA GAC CAA GGT TTT CCA GGT ACA AAA GGA TCA CTG gly pro lys gly asp gln gly phe pro gly thr lys gly ser leu 720 GGT TGT CCT GGA AAA ATG GGA GAG CCT GGG TTA CCT GGA AAG CCA gly cys pro gly lys met gly glu pro gly leu pro gly lys pro 735 GGC CTC CCA GGA GCC AAG GGA GAA CCA GCA GTA GCC ATG CCT GGA gly leu pro gly ala lys gly glu pro ala val ala met pro gly 750 GGA CCA GGA ACA CCA GGT TTT CCA GGA GAA AGA GGC AAT TCT GGG gly pro gly thr pro gly phe pro gly glu arg gly asn ser gly 765 GAA CAT GGA GAA ATT GGA CTC CCT GGA CTT CCA GGT CTC CCT GGA glu his gly glu ile gly leu pro gly leu pro gly leu pro gly 780 ACT CCA GGA AAT GAA GGG CTT GAT GGA CCA CGA GGA GAT CCA GGG thr pro gly asn glu gly leu asp gly pro arg gly asp pro gly 795 CAG CCT GGA CCA CCT GGA GAA CAA GGA CCC CCA GGA AGG TGC ATA gln pro gly pro pro gly glu gln gly pro pro gly arg cys ile 810 GAG GGT CCC AGG GGA GCC CAA GGA CTT CCA GGC TTA AAT GGA TTG glu gly pro arg gly ala gln gly leu pro gly leu asn gly leu 825 AAA GGG CAA CAA GGC AGA AGA GGT AAA ACG GGG CCA AAG GGA GAC lys gly gln gln gly arg arg gly lys thr gly pro lys gly asp 840 CCA GGA ATT CCA GGC TTG GAT AGA TCA GGA TTT CCT GGA GAA ACT pro gly ile pro gly leu asp arg ser gly phe pro gly glu thr 855 GGA TCA CCA GGA ATT CCA GGT CAT CAA GGT GAA ATG GGA CCA CTG gly ser pro gly ile pro gly his hln gly glu met gly pro leu 870 GGT CAA AGA GGA TAT CCA GGA AAT CCG GGA ATT TTA GGG CCA CCA gly gln arg gly tyr pro gly asn pro gly ile leu gly pro pro 885 GGT GAA GAT GGA GTG ATT GGG ATG ATG GGA TTT CCT GGA GCC ATT gly glu asp gly val ile gly met met gly phe pro gly ala ile 900 GGC CCT CCA GGG CCC CCT GGG AAC CCA GGC ACA CCA GGG CAC AGG gly pro pro gly pro pro gly asn pro gly thr pro gly his arg 915 GGG AGC CCT GGA ATT CCA GGA GTA AAG GGC CAG AGA GGA ACC CCA gly ser pro gly ile pro gly val lys gly gln arg gly thr pro 930 GGA GCC AAG GGG GAA CAA GGA GAT AAA GGA AAT CCC GGG CCT TCA gly ala lys gly glu gln gly asp lys gly asn pro gly pro ser 945 GAG ATA TCC CAC GTA ATA GGG GAC AAA GGA GAA CCA GGT CTC AAA glu ile ser his val ile gly asp lys gly glu pro gly leu lys 960 GGA TTC GCA GGA AAT CCA GGT GAG AAA GGA AAC AGA GGC GTT CCA gly phe ala gly asn pro gly glu lys gly asn arg gly val pro 975 GGG ATG CCA GGT TTA AAG GGC CTC AAA GGA CTA CCC GGA CCA GCA gly met pro gly leu lys gly leu lys gly leu pro gly pro ala 990 GGA CCA CCA GGC CCC AGA GGA GAT TTG GGC AGC ACT GGG AAT CCT gly pro pro gly pro arg gly asp leu gly ser thr gly asn pro 1005 GGA GAA CCA GGA CTC CTT GGT ATA CCA GGA AGC ATG GGG AAC ATG gly glu pro gly leu leu gly ile pro gly ser met gly asn met 1020 GGC ATG CCA GGT TCT AAA GGA AAA AGG GGA ACT TTG GGA TTC CCA gly met pro gly ser lys gly lys arg gly thr leu gly phe pro 1035 GGT CGA GCA GGA AGA CCA GGC CTC CCA GGT ATT CAT GGT CTC CAG gly arg ala gly arg pro gly leu pro gly ile his gly leu gln 1050 GGA GAT AAG GGA GAG CCA GGT TAT TCA GAA GGT ACA AGG CCA GGA gly asp lys gly glu pro gly tyr ser glu gly thr arg pro gly 1065 CCA CCG GGA CCA ACG GGG GAT CCA GGA CTG CCG GGT GAT ATG GGA pro pro gly pro thr gly asp pro gly leu pro gly asp met gly 1080 AAG AAA GGA GAA ATG GGG CAA CCT GGC CCA CCT GGA CAT TTG GGG lys lys gly glu met gly gln pro gly pro pro gly his leu gly 1095 CCT GCT GGA CCT GAG GGA GCC CCT GGA AGT CCT GGA AGT CCT GGC pro ala gly pro glu gly ala pro gly ser pro gly ser pro gly 1110 CTC CCA GGA AAG CCA GGT CCT CAT GGT GAT TTG GGT TTT AAA GGA leu pro gly lys pro gly pro his gly asp leu gly phe lys gly 1125 ATC AAA GGC CTC CTG GGC CCT CCA GGA ATC AGA GGC CCT CCA GGT ile lys gly leu leu gly pro pro gly ile arg gly pro pro gly 1140 CTT CCA GGA TTT CCA GGA TCT CCT GGA CCA ATG GGT ATA AGA GGT leu pro gly phe pro gly ser pro gly pro met gly ile arg gly 1155 GAC CAA GGA CGT GAT GGA ATT CCT GGT CCA GCC GGA GAA AAG GGA asp gln gly arg asp gly ile peo gly pro ala gly glu lys gly 1170 GAA ACG GGT TTA TTG AGG GCC CCT CCA GGC CCA AGA GGG AAC CCT glu thr gly leu leu arg ala pro pro gly pro arg gly asn pro 1185 GGT GCT CAA GGA GCC AAA GGA GAC AGG GGA GCC CCA GGT TTT CCT gly ala gln gly ala lys gly asp arg gly ala pro gly phe pro 1200 GGC CTC CCG GGC AGA AAA GGG GCC ATG GGA GAT GCT GGA CCT CGA gly leu pro gly arg lys gly ala met gly asp ala gly pro arg 1215 GGA CCC ACA GGC ATA GAA GGA TTC CCA GGG CCA CCA GGT CTG CCC gly pro thr gly ile glu gly phe pro gly pro pro gly leu pro 1230 GGT GCA ATT ATC CCT GGC CAG ACA GGA AAT CGT GGT CCA CCA GGC gly ala ile ile pro gly gln thr gly asn arg gly pro pro gly 1245 TCA AGA GGA AGC CCA GGT GCG CCT GGT CCC CCT GGA CCT CCA GGG ser arg gly ser pro gly ala pro gly pro pro gly pro pro gly 1260
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