Gene: [00.0/ATP2C] ATPase, Ca++ transporting, platelet?;
|
FUN |
Systematic name: ATP phosphohydrolase (Ca(2+)-transporting). The reaction catalyzed: ATP + H(2)O = ADP + orthophosphate." |
|
FAG |
This isoform is assigned to a group of Ca-dependent ATPases, which total number is not known yet. Two other genes, ATP2A1 (skeletal muscle) and ATP2A2 (cardiac muscle), are mapped to chrs 16 and 12, respectively; however, a third isoform (platelet) is supposed to exist. The tissue variability of Ca-dependent ATPases is also accounted for by the heterogeneity of their forms due to alternative splicing. This group is included in the transporting ATPases multigene family, together with Na,K-dependent and H-dependent ATPases (see FAM:ATP/00.0)." |
|
REL |
GEM:16p121/ATP2A1. |
|
REF |
FUN,PEP "Fischer &: JBC, 260, 8996-9001, 1985 PRO,EXP "Lytton J, MacLennan: JBC, 263, N29, 15024-15031, 1988 |
|
KEY |
neu, mem, ion |
|
CLA |
coding, basic |
|
LOC |
RS |
|
MIM |
? |
|
EZN |
ENZYME: 3.6.1.38 |
