Gene: [00.0/HAS1] hyaluronan synthase 1;


FUN

Hyaluronan is an unbranched glycosaminoglycan composed of repeating disaccharide units. It is a major constituent of the extracellular matrix and has been implicated in development, tumorigenesis, and several diseases. Hyaluronan is synthesized at the inner face of the plasma membrane and is subsequently extruded to the outside of the cell."

FAG

The following genes coding for hyaluronan synthase have been found: GEM:00.0/HAS2; GEM:16q221/HAS3."

REF

CLO,SEQ,EXP "Itano N, Kimata K: BBRC, 222, 816-820, 1996a
CLO,SEQ,EXP "Itano N, Kimata K: JBC, 271, 9875-9878, 1996b
CLO,SEQ,EXP "Shyjan AM &: JBC, 271, 23395-23399, 1996

KEY

onc, exce

CLA

coding, basic

LOC

RS

MIM

MIM: 601463

EZN

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