Gene: [00.0/PTPN8] protein tyrosine phosphatase, non-receptor type 8 (PEST-containing);
|
PEP |
[1] PTPN8 cDNA was shown to contain a large carboxy-terminal domain of
approximately 500 amino acids that is rich in PEST (proline, glutamic
acid, serine, and threonine) motifs. Such domains are characteristic of
proteins that are rapidly degraded. The PTPN8 cDNA was found to code
for an 802-amino acid protein with a predicted molecular weight of 89.7
kDa (Matthews-1992).
[2] The amino acid sequence of the phosphatase domain was about 35% similar to the phosphatase domains of other PTPases (FAM:PTP/00.0)." |
|
FUN |
[1] Systematic name: protein-tyrosine-phosphate phosphohydrolase.
[2]-Reaction catalyzed: protein tyrosine phosphate + H(2)O = protein tyrosine + orthophosphate." |
|
REL |
See GEM:20q13/PTPN1. |
|
REF |
COD,SEQ,FAG "Matthews RJ &: Mol Cell Biol, 12, 2396-2405, 1992 |
|
KEY |
pep |
|
CLA |
coding, basic |
|
LOC |
RS |
|
MIM |
MIM: 600716 |
|
EZN |
ENZYME: 3.1.3.48 |
