Gene: [00.0/RVTL1S1] human T-cell lymphotropic virus-1 site integration 1; multiple sclerosis (disseminated sclerosis)?; tropical spastic paraparesis?; [MS MSSG ]

COM	MIM does not consider this marker (MIM:126200) as independent, since it has been assumed to be tightly linked to the HLA complex in chr 6p (MS susceptibility gene, MSSG)."
FAG	Mengle-Gaw/Rabbitts-1987 discussed the possible site of HTLV1 retrovirus insertion within the chr 8 PVTL locus (GEM:08q241/MYCA). This would activate the MYC oncogene and lead to malignancy. However, the identity of this site to the reserved *RVTL1S1 is not determined."
HIS	Reddy-1988 (the laboratory of H.Koprowski, The Wistar Institute, Philadelphia) demonstrated that multiple sclerosis patients express some antigens of human T-cell lymphotropic virus (HTLV-1), the provirus genome being integrated into lymphocyte DNA, from which it can be cloned."
REF	PHE,FOG "Currier, Eldridge: Arch Neurol, 39, (Mar), 140-144, 1982 PHE,FOG "Ebers &: New Engl J Med, 315, 1638-1642, 1986 LIN "Francis &: Tissue Antigens, 29, 7-12, 1987 PAT "Gaiser CN &: J Clin Invest, 79, 309-313, 1987 LIN "Haile RW &: Clin Genet, 18, 160-167, 1980 PAT "Reddy &: PNAS, 85, N10, 3599-3603, 1988 PHE,FOG "Sadovnick &: Am J Med Genet, 8, 355-361, 1981a PHE,FOG "Sadovnick, Macleod: Neurology, 31, 1039-1041, 1981b PAT "Salier &: J Clin Invest, 78, 533-538, 1986 LIN "Tiwari JL &: AJHG, 32, 103-111, 1980 PHE,FOG "Williams &: Neurology, 30, 1139-1147, 1980
KEY	imm, neu, vir
CLA	unknown, basic
LOC	RS
MIM	MIM: 126200
SYN	MS MSSG