Gene: [01p13/CD2] antigen CD2 (p50; mono-antibodies Leu5, T11, 9.6, 35.1); sheep red blood cell receptor; antigen CD58 receptor (rosette receptor); [GP50 SRBC ]

GEN	The gene length is 12 kb; exons: 5.
MOP	The product is a transmembrane glycoprotein with the MM 50 kD; the MM of apoprotein is 38 kD (about 330 amino acid residues); it consists of three domains, the extracellular, membrane, and cytoplasmic ones (180, 40, and 110 amino acid residues, respectively)."
EVO	The peptide has confined regions that are homologues to the amino acid sequences of immunoglobulins."
REL	GEM:01p13/CD58.
FUN	The CD2 antigen is supposed to participate in T cell activation.
REF	LOC "Brown MH &: Hum Genet, 76, 191-195, 1987 LOC,CAG "Clayton &: J Immunol, 140, 3617-3621, 1988 CAG,GEN,SEQ "Diamond DJ &: PNAS, 85, N5, 1615-1619, 1988 GEN,STR,EXP,ENG "Lang G &: EMBO J, 7, N6, 1675-1682, 1988 FUN,MEB "Parish &: J Immunol, 141, N10, 3498-3504, 1988 PRO,SEQ,MOP,FAG "Sayre PH &: PNAS, 84, N9, 2941-2945, 1987 PRO,SEQ,MOP,FAG "Seed B, Aruffo: PNAS, 84, N10, 3365-3369, 1987 PRO,SEQ,MOP,FAG "Sewell WA &: PNAS, 83, N22, 8718-8722, 1986
SWI	SWISSPROT: P06729
KEY	imm, img, recp, mem
CLA	coding, basic
LOC	01 p13
MIM	MIM: 186990
SYN	GP50 SRBC