Gene: [01p363/CDC2L1] cell division cycle 2-like 1 (PITSLRE B); protein kinase p58/GTA, galactosyltransferase associated; PITSLRE protein kinase B;

COM	Cdc2L1 and Cdc2L2 (GEM:01p363/CDC2L2) span approximately 140kb on Chr 1p36.3. The products of these genes encode almost identical PITSLRE protein kinases which have functions that may be relevant to the regulation of transcription/splicing and apoptotic signalling. Gururajan-1998 reports that Chr 1p36.3 consists of two identical genomic regions each of which contain a Cdc2L gene linked to a metalloprotease (MMP) gene in tail-to-tail configuration (GEM:01p363/MMP21 and GEM:01p363/MMP22) and also linked tightly to variable number tandem repeat D1Z2 (GEM:01p363/D1Z2). They are organized as follow: pter - D1Z2 - 5'-MMP22-3' - 3'-Cdc2L2-5' - 5'Cdc2L1-3' - 3'-MMP21-5' - pcen."
FAG	The CDC2 factor is mapped to Chr 10q21.1 (GEM:10q211/CDC2).
REF	SEQ "Bunnell BA &: PNAS, 87, N19, 7467-7471, 1990 GEN,SEQ,EXP "Easton J &: Gene, 145, 279-282, 1994 GEN,SEQ,EXP "Eipers PG &: Genomics, 13, N3, 613-621, 1992 CLO,LOC "Eipers PG &: Genomics, 11, N3, 621-629, 1991 CLO,SEQ,GEN,LOC "Gururajan R &: Genome Res, 8, N9, 929-939, 1998 GEN,SEQ,EXP "Lahti JM &: Nature Genet, 7, 370-375, 1994
KEY	repr, pep
CLA	coding, basic
LOC	01 p36.3
MIM	MIM: 176873
EZN	ENZYME: 2.7.1.?