Gene: [01p363/RNU1A] RNA, U1 small nuclear (gene cluster of 10-30 functional copies); [RNU1 ]


COM

This chromosome subsegment contains several copies of the gene in question. Different research groups reported contradictory conclusions regarding both the exact regional location and the approximate number of the gene copies; see 'Functional_genomics'."

FAG

[1] RNU1 is supposed to constitute a part of a cluster which comprises up to 12 (Buckland-1989), 15 (Bernstein-1985), or 28 (Lund-1984) functionally active gene copies (per haploid genome). The other part comprises approximately the same number of gene copies encoding asparagine (Asn/N) and glutamic acid (Glu/E) tRNAs (GEM:01p363/TRN; GEM:01p363/TRE). In addition, there is another cluster of the same genes that are apparently pseudogenes and reside in the long arm of the same chromosome (see GEM:01q/RNU1P1). According to Buckland-1989, the latter cluster contains up to 48 RNU1 pseudogenes/haploid genome.
[2] See also GEM:00.0/RNU1B (reserved as murine homolog); GEM:17p1/RNU3.
[3] According to the Naylor-1984's data obtained by in situ hybridization, the RNU1 gene cluster resides in subsegment 1p36.3; however, all of the last releases of the HGMW Catalogue refer to a different subsegment - 1p36.1. The same contradictory conclusion relates to the regional chromosome location of the tRNA genes mentioned above."

PSG

GEM:01q/RNU1P1; GEM:01q/RNU1P2; GEM:01q/RNU1P3; GEM:01q/RNU1P4.

REF

CLO,SEQ,EXP,EVO "Bernstein LB &: Mol Cell Biol, 5, 2159-2171, 1985
FUN,MOL "Black DL &: Cell, 42, 737-750, 1985
LOC,CYG,MOL "Bostock CJ &: CCG, 37 (HGM7), N1-4, 424-425, 1984
LOC,CYG,MOL "Hamerton JL &: CCG, 37 (HGM7), N1-4, 3-21, 1984
FUN,MOL "Krainer AR, Maniatis T: Cell, 42, 725-736, 1985
TRC,REG,STR,NTC "Kunkel GR, Pederson T: Genes Dev, 2, 196-204, 1988
LOC,CYG,MOL "Lindgren V &: Mol Cell Biol, 5, 2172-2180, 1985
FAG,POL,MOL "Lund E, Dahlberg JE: JBC, 259, 2013-2021, 1984
LOC,CYG,MOL "Lund E &: Mol Cell Biol, 3, 2211-2220, 1983
FAG,POL,MOL "Manser T, Gesteland RF: Cell, 29, 257-264, 1982
LOC,CYG,MOL "Naylor SL &: Somat Cell Mol Genet, 10, 307-313, 1984

KEY

trc

CLA

coding, basic

LOC

01 p36.3

MIM

MIM: 180680

SYN

RNU1