Gene: [01p36/CORT] cortistatin;


SUM

Cortistatin is a 14-residue putative neuropeptide with strong structural similarity to somatostatin (GEM:03q28/SST) and is expressed predominantly in cortical GABAergic interneurons. Administration of cortistatin into the brain ventricles of rats specifically enhances slow-wave sleep, presumably by antagonizing the effects of acetylcholine on cortical excitability (de Lecea-1997)."

REF

COD,SEQ,EVO,LOC "de Lecea L &: Genomics, 42, 499-506, 1997
CLO,SEQ "Fukusumi S &: BBRC, 232, 157-163, 1997

KEY

neu

CLA

coding, basic

LOC

01 p36

MIM

MIM: 602784