Gene: [01p36/HVEM] herpes virus entry mediator; [TR2 ATAR ]


FUN

[1] HVEM is suggested to play an important role in herpesvirus pathogenesis because it enhanced the entry of several wildtype HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T cells (Montgomery-1996).
[2] In vivo, epitope-tagged HVEM interacts with several TNFR-associated factor (TRAF) proteins, including TRAF1 (GEM:09q3/TRAF1), TRAF2 (GEM:00.0/TRAF2), TRAF3 (GEM:00.0/TRAF3), and TRAF5 (GEM:01q32/TRAF5). HVEM is linked via TRAFs to signal transduction pathways that activate the immune response (Marsters-1997)."

MOP

The HVEM gene is a member of the TNFR family (see GEM:12p13/TNFR1). The HVEM protein contains N-terminal signal peptide, 2 potential sites for addition of N-linked glycans, a putative membrane-spanning domain, and a cysteine-rich repeat region characteristic of TNFR famil members, and shared 17 to 25% amino acid identity with other TNFRs (Montgomery-1996)."

REF

CLO,EXP "Hsu H &: JBC, 272, N21, 13471-13474, 1997
CLO,EXP,LOC "Kwon BS &: JBC, 272, N22, 14272-14276, 1997
EXP,FUN "Masters SA &: JBC, 272, N22, 14029-14032, 1997
CLO,SEQ,MOP,FUN "Montgomery RI &: Cell, 87, N3, 427-436, 1996

KEY

recp, vir, imm

CLA

coding, basic

LOC

01 p36.3-.22

MIM

MIM: 602746

SYN

TR2 ATAR