Gene: [01p36/ILA] interleukin-activated receptor, homolog of mouse Ly63; antigen CD137 (induced by lymphocyte activation; ILA); [CD137 Ly63 ]

COM	The CD137/ILA gene was localized to Chr 1p36 by somatic cell hybrid analysis (Schwarz-1997)."
FUN	CD137 inhibits proliferation of activated T lymphocytes and induces programmed cell death (Schwarz-1996)."
MOP	The CD137 gene encodes a 255-amino acid protein with 3 cysteine-rich motifs in the extracellular domain, a transmembrane region, and a short N-terminal cytoplasmic portion containing potential phosphorylation sites."
FAG	CD137 is a member of the tumor necrosis factor receptor family (see GEM:12p13/TNFR1). Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiologic processes and play an important role in the regulation of immune responses. ILA is expressed by activated T- and B-lymphocytes and monocytes."
REF	SEQ,EVO,LOC "Schwarz H &: BBRC, 235, N3, 699-703, 1997 COD,EXP "Schwarz H &: Blood, 87, N7, 2839-2845, 1996 CLO,EXP,FUN "Schwarz H &: Gene, 134, N2, 295-298, 1993
KEY	recp, mem, onc
CLA	coding, basic
LOC	01 p36
MIM	MIM: 602250
SYN	CD137 Ly63