Gene: [01q3/PTPRC] protein tyrosine phosphatase, receptor type, c polypeptide; antigen CD45 (LCA; T200 glycoprotein);


COM

Immunologists use a symbol CD45R, which designates only high-molecular forms, p205 and p220. They are expressed on T and/or B lymphocytes and possess common antigenic determinants that are not characteristic for other CD45 proteins."

MOP

[1] Antigen CD45 is identified with monoclonal antibodies HLE-1, UCHL1, S-54, 2H4.
[2] Protein products of this locus resulted from the alternative splicing constitute a family of leukocyte glycoproteins with MM 180 kD (p180), 190 kD (p190), 205 kD (p205), and 220 kD (p220). Each of these molecular forms is heterogeneous in its carbohydrate group composition and, as a result, in antigenic properties."

FUN

Systematic name: protein-tyrosine-phosphate phosphohydrolase. Reaction catalyzed: protein tyrosine phosphate + H(2)O = = protein tyrosine + orthophosphate."

REL

See GEM:20p13/PTPRA.

REF

LOC,CYG,MOL "Akao &: Somat Cell Mol Genet, 13, 273-278, 1987
IDN,FUN,MEB "Clark, Ledbetter: Immunol Today, 10, N7, 225-228, 1989
EXP,FUN,HUM "Deans &: J Immunol, 143, N4, 1233-1238, 1989
PRO,COD,SEQ,GEN,TRC,EVO "Johnson NA &: JBC, 264, N11, 6220-6229, 1989
EXP,FUN,HUM "Pilarski &: Eur J Immunol, 19, 589-597, 1989
EXP,FUN,HUM "Pulido &: FEBS Lett, 249, N2, 337-342, 1989
PRO,SEQ,EXP,LOC "Ralph SJ &: EMBO J, 6, 1251-1257, 1987
SEQ,EXP,EVO,MOU "Saga Y &: PNAS, 83, N18, 6940-6944, 1986
EXP,FUN,HUM "Takeuchi &: Eur J Immunol, 19, 747-755, 1989
SEQ,EXP,EVO,MOU "Thomas &: PNAS, 84, N15, 5360-5363, 1987

SWI

SWISSPROT: P08575

KEY

hem, imm, pep, recp

CLA

coding, basic

LOC

01 q31-32

MIM

MIM: 151460

EZN

ENZYME: 3.1.3.48

Смотрите также:

  • Ген CD45
  • HUGEN-CD45