Gene: [01q3/PTPRC] protein tyrosine phosphatase, receptor type, c polypeptide; antigen CD45 (LCA; T200 glycoprotein);
COM | Immunologists use a symbol CD45R, which designates only high-molecular forms, p205 and p220. They are expressed on T and/or B lymphocytes and possess common antigenic determinants that are not characteristic for other CD45 proteins." |
MOP | [1] Antigen CD45 is
identified with monoclonal antibodies HLE-1, UCHL1, S-54, 2H4. [2] Protein products of this locus resulted from the alternative splicing constitute a family of leukocyte glycoproteins with MM 180 kD (p180), 190 kD (p190), 205 kD (p205), and 220 kD (p220). Each of these molecular forms is heterogeneous in its carbohydrate group composition and, as a result, in antigenic properties." |
FUN | Systematic name: protein-tyrosine-phosphate phosphohydrolase. Reaction catalyzed: protein tyrosine phosphate + H(2)O = = protein tyrosine + orthophosphate." |
REL | See GEM:20p13/PTPRA. |
REF | LOC,CYG,MOL "Akao &: Somat Cell Mol Genet, 13, 273-278,
1987 IDN,FUN,MEB "Clark, Ledbetter: Immunol Today, 10, N7, 225-228, 1989 EXP,FUN,HUM "Deans &: J Immunol, 143, N4, 1233-1238, 1989 PRO,COD,SEQ,GEN,TRC,EVO "Johnson NA &: JBC, 264, N11, 6220-6229, 1989 EXP,FUN,HUM "Pilarski &: Eur J Immunol, 19, 589-597, 1989 EXP,FUN,HUM "Pulido &: FEBS Lett, 249, N2, 337-342, 1989 PRO,SEQ,EXP,LOC "Ralph SJ &: EMBO J, 6, 1251-1257, 1987 SEQ,EXP,EVO,MOU "Saga Y &: PNAS, 83, N18, 6940-6944, 1986 EXP,FUN,HUM "Takeuchi &: Eur J Immunol, 19, 747-755, 1989 SEQ,EXP,EVO,MOU "Thomas &: PNAS, 84, N15, 5360-5363, 1987 |
SWI | SWISSPROT: P08575 |
KEY | hem, imm, pep, recp |
CLA | coding, basic |
LOC | 01 q31-32 |
MIM | MIM: 151460 |
EZN | ENZYME: 3.1.3.48 |
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