Gene: [01q4/KCNK1] potassium inwardly-rectifying channel, subfamily K, member 1; potassium channel, weakly inward-rectifying, with twin P domains; [DPK TWIK1 ]

COM	The KCNK1/TWIK1 gene was mapped to Chr 1q42-43 by in situ hybridization (Lesage-1996a)."
FUN	Potassium channels are functionally important to a large number of cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. When expressed in Xenopus oocytes, TWIK1 is able to direct expression of weakly inward-rectifying potassium currents. TWIK1 channels may be involved in the control of background potassium membrane conductances (Lesage-1996b)."
MOP	Unlike other potassium channels, KCNK1 has 4 (rather than 6) transmembrane domains and 2 (rather than 1) P domains (Lesage-1996b)."
REL	GEM:00.0/KCNK3.
REF	PRO,LOC "Lesage F &: Genomics, 34, N1, 153-155, 1996a COD,SEQ,PEP,EVO "Lesage F &: EMBO J, 15, N5, 1004-1011, 1996b
KEY	ion, mem
CLA	coding, basic
LOC	01 q42-43
MIM	MIM: 601745
SYN	DPK TWIK1