Gene: [02p241/MYCN] avian myelocytomatosis viral related oncogene; [NMYC]
FAG | MYCN is a component of the multigene family of MYC protooncogenes (see GEM:08q241/MYC)." |
TIS | Relatively tissue-specific, intensive expression is characteristic for MYCN (in contrast to MYC1). This is related to either pronounced amplification of the locus (predominantly in tumors that are developed from primitive cells, e.g., in neuroblastomas) or enhanced expression without amplification (as is the case for developing kidney or for Wilms tumor)." |
EXP | MYCN amplification in neuroblastomas reflects a pronounced progression of tumor and increasing metastatic spreading. It is important that the amplificated copies of MYCN are found most frequently in other chromosomes rather than the standard locus of the unique gene on chr 2p." |
GEN | The gene length is 6.6 kb. Exons: 3; the first of them, in the 5'-region of the processed transcript, is not translated; the second and third exons code for the protein with MM 49 kD consisting of 456 amino acid residues." |
REF | REV,GEN,EVO "Alt &: Cold Spring Harbor Symp, 51, (Part 2),
931-941, 1986 EXP,PAT,CYG "Brodeur GM, Seeger: Cancer Genet Cytogenet, 19, 101-111, 1986 EXP,PAT,CYG "Brodeur GM &: Science, 224, 1121-1124, 1984 EXP,PAT,CYG "Christiansen &: Cancer Genet Cytogenet, 26, 235-244, 1987 EXP,PAT,CYG "Emanuel &: PNAS, 82, (Jun), 3736-3740, 1985 EXP,PAT,CYG "Garson JA &: CCG, 45, 10-15, 1987a PRO,LOC "Garson JA &: NAR, 15, 4761-4770, 1987b PRO,LOC "Kanda N &: PNAS, 80, 4069-4073, 1983 MUT,MOL,PAT,FAG "Kato &: FEBS Lett, 250, N2, 529-535, 1989 EXP,PAT,CYG "Kinzler KW &: PNAS, 83, N4, 1031-1035, 1986 GEN,SEQ,MOP "Kohl NE &: Nature, 319, 73-77, 1986 EXP,PAT,CYG "Kohl NE &: Science, 226, 1335-1337, 1984 EXP,PAT,CYG "Kohl NE &: Cell, 35, 359-367, 1983 EXP,PAT,CYG "Lee &: Nature, 309, 458-460, 1984 GEN,SEQ,MOP "Michitsch RW, Melera: NAR, 13, 2545-2558, 1985 GEN,SEQ,MOP "Ramsay &: Mol Cell Biol, 6, 4450-4457, 1986 EXP,PAT,CYG "Schwab M: Trends Genet, 1, 271-275, 1985 PRO,LOC "Schwab M &: Nature, 308, (15 Mar), 288-291, 1984a EXP,PAT,CYG "Schwab M &: PNAS, 81, 4940-4944, 1984b EXP,PAT,CYG "Schwab M &: Nature, 305, (15 Sep), 245-248, 1983 EXP,PAT,CYG "Seeger &: New Engl J Med, 313, 1111-1116, 1985 EXP,PAT,CYG "Shiloh Y &: PNAS, 82, 3761-3765, 1985 GEN,SEQ,MOP "Stanton LW &: PNAS, 83, N6, 1772-1776, 1986 EXP,PAT,CYG "Thiele &: Nature, 313, (31 Jan), 404-406, 1985 EXP,PAT,CYG "Zehnbauer &: Mol Cell Biol, 8, N2, 522-530, 1988 |
SWI | SWISSPROT: P04198 |
KEY | onc |
CLA | coding, basic |
LOC | 02 p24.1 |
MIM | MIM: 164840 |
SYN | NMYC |
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