Gene: [02p2/CAD] CAD trifunctional protein; carbamoyl phosphate synthetase 2, soluble (EC:6.3.4.16); aspartate transcarbamylase (EC:2.1.3.2); dihydroorotase (EC:3.5.2.3);

COM	Some sources indicate an old enzyme code, EC:2.7.2.5.
FUN	CAD gene codes for a protein that possesses three different enzymatic activities and thus catalyzes the first three stages of pirimidine biosynthesis (those are six for uridine and nine for cytidine). The fourth stage is catalyzed by dihydroorotate dehydrogenase (EC:1.3.3.1), which gene has not been found yet; the fifth and sixth stages are controlled by the same gene, which codes for a bifunctional enzyme, OPRT/orotate phosphoribosyl transferase and UMPS/orotidine-5'-phosphate decarboxylase (GEM:03q13/UMPS)."
FAG	Another isoform, carbamoyl phosphate synthetase 1 (mitochondrial) was revealed, which deficiency causes hyperammonemia II (GEM:02q35/CPS1)."
REF	GEN,PRO,LOC "Chen &: Hum Genet, 82, 40-44, 1989 LOC,PRO "Chen &: AJHG, 41, A161, 1987 FUN,PRO "De Saint Vincent &: Cell, 27, (Dec, Part I), 267-277, 1981 FUN,PRO "Meinkoth &: Mol Cell Biol, 7, N4, 1415-1424, 1987 FUN,PRO "Padgett RA &: Mol Cell Biol, 2, 293-301, 1982 LOC,MOL,CYG "Rocchi &: CCG, 46, (HGM9), 682-683, 1987 FUN,PRO "Shigesada &: Mol Cell Biol, 5, 1735-1742, 1985
SWI	SWISSPROT: P27708
KEY	nucm, urea, repr
CLA	coding, basic
LOC	02 p22-21
MIM	MIM: 114010
EZN	ENZYME: 2.1.3.2