Gene: [02q1/BUB1] budding uninhibited by benzimidazoles 1 (yeast homolog); mitotic checkpoint protein kinase BUB1; colorectal cancer with chromosomal instability;
|
COM |
[1] The BUB1 gene was mapped to Chr 2q12-14 by fluorescence in situ
hybridization (Cahill-1998).
[2] BUB1 is a prototype member of a family of genes, some of which encode proteins that bind to the kinetochore and all of which are required for a normal mitotic delay in response to spindle disruption." |
|
DOM |
The BUB1 protein contains 2 highly conserved domains: CD1 and CD2. CD1 directs kinetochore localization and binding to Bub3 (GEM:10q24/BUB3), whereas CD2 encodes the kinase domain." |
|
REL |
GEM:15q/BUB1B. |
|
REF |
COD,SEQ,LOC,MUT,DOM "Cahill DP &: Nature, 392, N6673, 300-303, 1998 CLO,SEQ,EXP,LOC "Pangilinan F &: Genomics, 46, N3, 379-388, 1997 |
|
KEY |
onc |
|
CLA |
coding, basic |
|
LOC |
02 q12-14 |
|
MIM |
MIM: 602452 |
|
EZN |
? |
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