Gene: [02q1/COX5B] cytochrome c oxidase subunit Vb;
GEN | [1] The
gene length is 22.4 kb (or more). Exons: 5; introns: 4. [2] The structural characteristics of COX5B gene (the increased frequency of CpG dinucleotide in the 5'-vicinity, the lack of TATA and CAAT boxes, the presence of GC boxes, which represent binding sites for transcriptional factor SP1) allow to assign this gene to the group of housekeeping genes (Lomax-1991)." |
FUN | Systematic name is ferrocytochrome c: oxigen oxidoreductase. |
MOP | The holoenzyme, cytochrome c oxidase, consists of 13 subunits, three of them being encoded by mitochondrial genes and 10, by nuclear genes." |
FAG | Coding human COX5B gene has been found in chr 2, and seven COX5B-like genes have been found in different chromosomes: GEM:04q/COX5BL1; GEM:06^/COX5BL2; GEM:07^/COX5BL3; GEM:11q/COX5BL4; GEM:12^/COX5BL5; GEM:13^/COX5BL6; and GEM:22^/COX5BL7 (Lomax-1991)." |
REF | PRO,GEN,LOC,FAG "Lomax MI &: Genomics, 10, N1, 1-9, 1991 PRO,COD,SEQ,EVO,HUM,MAM "Zeviani M &: Gene, 65, 1-11, 1988 |
SWI | SWISSPROT: P10606 |
KEY | mito |
CLA | coding, basic |
LOC | 02 q11-13 |
MIM | MIM: 123866 |
EZN | ENZYME: 1.9.3.1 |
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