Gene: [02q2/ACVR1] activin A receptor, type I (65kD); activin A receptor, type II-like kinase 2;
COM | The ACVR1 gene was mapped to Chr 2q23-q24 by fluorescence in situ hybridization (Roijer-1998)." |
FAG | [1] There are 2 classes of activin receptors, type
I and type II. identified 2 types of activin receptors (Mathews-1991). The
type I receptor has a molecular size of 65 kD, while the molecular size of
the type II receptor (see GEM:00.0/ACVR2A) is
85 kD. [2] About activins see FAM:INH/00.0." |
MOP | ACVR1 protein comprises a ligand-binding extracellular domain, a single membrane-spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity (Mathews-1991). Human ACVR1/ALK2 cDNA clones encode 4 putative transmembrane ser/thr kinases (ten Dijke-1993)." |
REF | CLO,FUN "Attisano L &: Cell, 75, N4, 671-680, 1993 COD,SEQ,EXP,FUN,FAG "Mathews LS, Vale WW : Cell, 65, 973-982, 1991 PRO,REL,SEQ "Matsuzaki K &: JBC, 268, 12719-12723, 1993 LOC,FAG "Roijer E &: Mammal Genome, 9, 266-268, 1998 PRO,SEQ,FAG,REL,TIS "ten Dijke P &: Oncogene, 8, 2879-2887, 1993 |
SWI | SWISSPROT: Q04771 |
KEY | recp |
CLA | coding, basic |
LOC | 02 q23-24 |
MIM | MIM: 102576 |
EZN | ENZYME: 2.7.1.37 |
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