Gene: [02q33/PTHR2] parathyroid hormone receptor 2; [PTHR2R ]
|
COM |
By FISH, the PTHR2 gene was mapped to 2q33 (Usdin-1996). |
|
MOP |
The PTHR2 gene product is a 7-transmembrane-domain G protein-coupled receptor that selectively recognizes parathyroid hormone (GEM:11p15/PTH) and is member of a family of G protein-coupled receptors referred to as the secretin receptor family (Usdin-1995). PTHR2 is most similar (51% overall amino acid identity) to the PTH/PTHLH receptor 1 (GEM:03p21/PTHR1). The gene is most abundantly expressed in brain, pancreas, testis, and placenta. The physiologic role of PTHR2 and its possible role in disease remained to be determined." |
|
REL |
GEM:02q141/SCTR. |
|
REF |
LOC "Usdin TB &: Genomics, 37, N1, 140-141, 1996 COD,SEQ,EXP "Usdin TB &: JBC, 270, 15455-15458, 1995 |
|
KEY |
recp, mem, horm |
|
CLA |
coding, basic |
|
LOC |
02 q33 |
|
MIM |
MIM: 601469 |
|
SYN |
PTHR2R |
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