Gene: [03p25/RAF1] murine leukemia viral homologue 1 (protooncogene RAF-1); [MIL ]
GEN | Exons: 17 or more. The length of the protein product is 648 amino acids." |
FAG | [1] The gene is a member of the multigene family of ras-like
oncogenes. [2] A pseudogene of this locus, which was previously referred to as RAF2 gene, has been mapped to chr 4p: GEM:04p161/RAF1P1." |
FUN | A viral homologue of this protooncogene possesses the serine/threonine-specific protein kinase activity (EC:2.7.1.-)." |
PRO | probe: vector cloning
site insertion in kb [1] p627: pUC13 EcoRI 2.9 [2] pF10-7: Okayama-Berg EcoRI 3.05 [3] pTUC8: pUC? EcoRI/HindIII 0.8" |
POL | [0] RFLP (Reference; Probe [n]) Alleles in kb/(Popul Freq)
[1] TaqI A-RFLP (Seizinger-1988; Pb[1]): A1= 6.8/(0.74); A2= 6.3/(0.26); [2] TaqI A-RFLP (Graziano-1988; Pb[2]): A1= 7.6/(0.73); A2= 7.0/(0.27); [3] BglI B-RFLP (Seizinger-1988; Pb[1]): B1= 4.0/(0.54); B2= 3.3/(0.46); [4] EcoRI C-RFLP (Graziano-1988; Pb[2]): C1= 14.4/(0.75); C2= 11.9/(0.25); [5] EcoRI C-RFLP (Dean-1989; Pb[3]): C1= 15.0/(0.86); C2= 12.0/(0.14)" |
REL | GEM:04p161/RAF1P1; GEM:07q34/BRAF; GEM:07q34/BRAFP; GEM:0Xp11/ARAF1; GEM:07p1/ARAF2." |
REF | PRO,SEQ,GEN,MOP,EXP
"Bonner TI &: NAR, 14, N2, 1009-1015, 1986 PRO,GEN,MOP,EXP,EAG "Bonner TI &: Mol Cell Biol, 5, 1400-1407, 1985 IDN,HUM,LOC,PRO,EAG "Bonner TI &: Science, 223, (6 Jan), 71-74, 1984 PRO,POL "Dean &: CCG, 51, (HGM10), 985, 1989 LOC,MAP,MOL "Gerber MJ &: AJHG, 43, 442-451, 1988 PRO,POL "Graziano SL &: Oncogene Res, 3, 99-103, 1988 FUN,EVO "Moelling &: Nature, 312, 558-561, 1984 PRO,GEN,EXP "Nakatsu &: Cold Spring Harbor Symp, 51, (Part 2), 1001-1008, 1986 IDN,MOU,PRO "Rapp UR &: PNAS, 80, 4218-4222, 1983 PRO,POL "Seizinger BR &: Nature, 332, 268-269, 1988 PRO,GEN,EXP "Shimizu K &: PNAS, 82, 5641-5645, 1985 FUN,EVO "Sutrave &: Nature, 309, 85-88, 1984 SEQ,GEN,EXP,ENG "Tahira &: NAR, 15, N12, 4809-4820, 1985 LOC,MAP,CYG "Teyssier JR &: J Nat Cancer Inst, 77, 1187-1191, 1986 |
KEY | onc |
CLA | coding, basic |
LOC | 03 p25 |
MIM | MIM: 164760 |
SYN | MIL |
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