Gene: [03p2/SCLC] small cell lung cancer; [SCCL SCLC1 ]
COM | This marker was excluded from the HGM10 catalogue, since its independence is not proved. The gene was localized by presumption to chromosome 3, on the basis of exlusively cytogenetic data (the phenomenon of loss of constitutional heterozygosity was used, that caused the clonal expression of the hypothetic recessive mutation leading to malignancy in hemizygotic cells). However, in this subsegment the protooncogene ERB-A2 (the gene for beta receptor of the thyroid hormone, GEM:03p243/THRB) is located, which is probably involved in pathogenesis of the small cell lung cancer (in a number of such tumors the loss of ERB-A2 gene was revealed by the direct method of the DNA probe diagnosis)." |
FAG | The SCLC gene is likely to interact with a fragile site FRA3B in which the frequency of aberrations is increased in small cell lung cancer (Liu-1989)." |
REF | IDN,PHE,PAT "Baylin &: PNAS, 79, 4650-4654, 1982 LOC "Brauch &: New Engl J Med, 317, 1109-1113, 1987 IDN,PHE,PAT "De Leij &: Cancer Res, 45, 6024-6033, 1985 LOC "Falor WH &: Cancer Genet Cytogenet, 16, 175-177, 1985 LOC "Graziano SL &: Cancer Res, 47, 2148-2155, 1987 LOC "Kok K &: Nature, 330, 578-581, 1987 PAT,FOG,LIN,CYG,REL "Liu CX &: Cancer Genet Cytogenet, 42, 107-114, 1989 LOC "Mooibroek H &: Cancer Genet Cytogenet, 27, 361-365, 1987 LOC "Naylor SL &: Nature, 329, 451-454, 1987 LOC "Naylor SL &: AJHG, 36, S35, 1984 IDN,PHE,PAT "Ruff &: Science, 225, 1034-1036, 1984 LOC "Whang-Peng J &: Cancer Genet Cytogenet, 6, 119-134, 1982a LOC "Whang-Peng J &: Science, 215, 181-182, 1982b LOC "Yokota J &: PNAS, 84, N24, 9252-9256, 1987 |
KEY | onc, pulm |
CLA | unknown, basic |
LOC | 03 p23-21 |
MIM | MIM: 182280 |
SYN | SCCL SCLC1 |
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