Gene: [03q1/TFG] TRK-fused gene (TRKT3 oncogene); [TRKT3 ]


COM

 The TFG gene was mapped to 3q11-q12 by FISH (Mencinger-1997).

FUN

 The thyroid TRK-T3 oncogene results from the fusion of the tyrosine kinase domain of NTRK1 (GEM:01q2/NTRK1) to sequences of TFG gene. The 68 kDa TRK-T3 fusion oncoprotein displays a constitutive tyrosine kinase activity resulting in its capability to transform mouse NIH3T3 cells. The TFG portion of TRK-T3 contains a coiled-coil domain most likely responsible for the constitutive, ligand-independent activation of the receptor tyrosine kinase activity (Greco-1995; Mencinger-1997)."

REF

 EXP,ABR "Greco A &: Oncogene, 16, N6, 809-816, 1998
ABR,EXP,COD "Greco A &: Mol Cell Biol, 15, 6118-6127, 1995
COD,SEQ,LOC,EXP "Mencinger M &: Genomics, 41, 327-331, 1997

KEY

 onc

CLA

 coding, basic

LOC

 03 q11-12

MIM

 MIM: 602498

SYN

 TRKT3