Gene: [03q21/MCM2] minichromosome maintenance deficient (S.cerevisiae) 2 (mitotin); cell division cycle-like 1 (mitotin); DNA replication licensing factor MCM2 (nuclear protein BM28); [CDC19 CDCL1 ]


FUN

The MCM genes were originally identified in yeast defective in minichromosome maintenance and have since been shown to play roles in the progression of the cell cycle (many are cell division control genes). MCMs 2 through 7 are thought to be "DNA licensing factors" which bind to the DNA after mitosis and enable DNA replication before being removed during S phase. The encoding genes are: GEM:06p/MCM3; GEM:08q112/MCM4; GEM:22q13/MCM5; GEM:02q21/MCM6; GEM:07q2/MCM7."

REF

LOC "Mincheva A &: CCG, 65, 276-277, 1994
LOC "Todorov IT &: BBRC, 177, 395-400, 1991

KEY

repr, trc

CLA

coding, basic

LOC

03 q21

MIM

MIM: 116945

SYN

CDC19 CDCL1