Gene: [03q29/TFRC] transferrin receptor (protein p90; antigen CD71, MFI2); [OKT9 MAP97 ]


COM

 [1] The TFRC gene was mapped to 3q29, close to the telomeric marker D3S2344, by linkage analysis, a panel of hybrid cell lines, GeneBridge 4 panel and FISH (Kashuba-1997).
[2] The GDB indicates the regional localization for TFRC as q26.2-qt [GDB:G00-120-433:Loc='03 q26.2-t'].
[3] The MIM catalogue describes 'melanoma-associated antigen p97' (MFI2, MAP97) under the number MIM:155750, as presumably identical to TFRC. However, the GDB describes MFI2 marker as an independent locus in region 3q28-29. Yet the HUGEN (as well as MIM) does not consider the gene MFI2 as independent."

GEN

 The gene length is 33.5 kb. Exons: 19.

FAG

 See GEM:03q21/TF.

POL

 [1] Gene-specific DNA probe pCPTR-1 (a 5 kb fragment) has been cloned at EcoRI site in the plasmid pTR36; ----------------------------- RFLP systems: ------------- RFLP name (Reference; Probe [number]): Alleles in kb/(Popul Freq) Const Bands (kb) ----------------------------------------------------------------------
[1] SacI A-RFLP (Kidd-1987; Probe [1]): A1= 8.5/(0.91); A2= 6.0/(0.09); CBs= 5.5;
[2] PvuII B-RFLP (Kidd-1987; Probe [1]): B1= 9.5/(0.08); B2= abs B1/(0.92); CBs= 10.5/7.0/6.5/4.5/4.2/4.0/1.0/0.75;
[3] TaqI C-RFLP (Kidd-1987; Probe [1]): C1= 2.0/(0.09); C2= abs C1/(0.91); CBs= 6.0/4.5/4.2/4.0"

REF

 GEN,MOP,EXP "Casey &: NAR, 16, N2, 629-646, 1988a
GEN,MOP,EXP "Casey &: PNAS, 85, N6, 1787-1791, 1988b
LOC,MAP,MOL "Enns CA &: PNAS, 79, 3241-3245, 1982
GEN,POL,EVO,SEQ "Evans P, Kemp J: Gene, 199, N1-2, 123-131, 1997
LOC,MAP,MOL "Goodfellow &: Somat Cell Genet, 8, 197-206, 1982
FUN,STR,REV "Hopkins CR: Cell, 40, (Jan), 199-208, 1985
FUN,STR,REV "Huebers, Finch: Physiol Rev, 67, 520-581, 1987
LOC,FAG "Kashuba VI &: FEBS Lett, 419, 181-185, 1997
PRO,POL "Kidd &: CCG, 46, (HGM9), 639, 1987
FUN,STR,REV "May, Cuatrecasas: J Membr Biol, 88, 205-215, 1985
CLO,SEQ,GEN,STR "McClelland A &: Cell, 39, (Dec, Part 1), 267-274, 1984
LOC,MAP,MOL "Miller YE &: AJHG, 35, N4, 573-583, 1983
GEN,MOP,EXP "Miskimins &: PNAS, 82, N20, 6741-6744, 1985
LOC,COM "Nikinmaa B, Schroder: Hereditas, 107, 55-58, 1987
GEN,MOP,EXP "Owen D, Kuhn: EMBO J, 6, N5, 1287-1293, 1987
LOC,MAP,MOL "Rabin M &: AJHG, 37, 1112-1116, 1985
GEN,MOP,EXP "Rothenberger &: Cell, 49, (May), 423-431, 1987
CLO,SEQ,EXP "Schneider C &: Nature, 311, (18 Oct), 675-678, 1984
CLO,SEQ,EXP "Schneider C &: EMBO J, 2, 2259-2263, 1983
EXP,MOP "Serke, Huhn: Brit J Haematol, 81, N3, 432-439, 1992
FUN,STR,REV "Trowbridge &: Biochem Pharmacol, 33, N6, 925-932, 1984
LOC,MAP,MOL "van de Rijn M &: CCG, 36, 525-531, 1983

KEY

 hem, trp, recp

CLA

 coding, basic

LOC

 03 q29

MIM

 MIM: 190010

SYN

 OKT9 MAP97