Gene: [03q2/ACPPS] acid phosphatase, prostate-specific;


FUN

The enzyme catalyzes the hydrolysis of monoethers of orthophosphoric acid and provides transphosphorylation. A physiologic role of this isoform in the prostate is not clear yet."

ASS

Isolation of this isoform of acid phosphatase is important in diagnosis of the prostate tumors."

FAG

Genes for other isoforms of acid phosphatase have been identified. Those are erythrocytic (GEM:02p25/ACP1), lysosomal (GEM:11p11/ACP2), and tartrate-resistant (GEM:19p132/ACP5) isoforms."

POL

[1] Gene-specific DNA probe PAP-1006A (a 0.8 kb fragment) has been cloned at EcoRI site in plasmid pUC18. ---------------------------------------------------------------------- RFLP name (Reference; Probe [number]): Alleles in kb/(Popul Freq) Const Bands (kb) ----------------------------------------------------------------------
[1] TaqI A-RFLP (Winqvist-1989; Probe [1]): A1= 8.0/(0.17); A2= 6.0/(0.83); CBs= no;
[2] TaqI B-RFLP (Winqvist-1989; Probe [1]): B1= 3.3/(0.39); B2= 2.2/(0.61); CBs= no"

REF

CLO,COD,SEQ,PEP,EVO,LOC "Sharief FS &: BBRC, 160, N1, 79-86, 1989
LOC,CYG,MOL,PRO,POL "Winqvist R &: CCG, 51, (HGM10), 1108, 1989a
LOC,CYG,MOL,PRO,POL "Winqvist R &: CCG, 52, 68-71, 1989b
CLO,COD,SEQ,EXP "Yeh LC &: Gene, 60, 191-196, 1987

KEY

sex, onc

CLA

coding, basic

LOC

03 q21.3-25.2

MIM

MIM: 171790

EZN

ENZYME: 3.1.3.2