Gene: [03q2/ACPPS] acid phosphatase, prostate-specific;
|
FUN |
The enzyme catalyzes the hydrolysis of monoethers of orthophosphoric acid and provides transphosphorylation. A physiologic role of this isoform in the prostate is not clear yet." |
|
ASS |
Isolation of this isoform of acid phosphatase is important in diagnosis of the prostate tumors." |
|
FAG |
Genes for other isoforms of acid phosphatase have been identified. Those are erythrocytic (GEM:02p25/ACP1), lysosomal (GEM:11p11/ACP2), and tartrate-resistant (GEM:19p132/ACP5) isoforms." |
|
POL |
[1] Gene-specific DNA probe PAP-1006A (a 0.8 kb fragment) has been
cloned at EcoRI site in plasmid pUC18.
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RFLP name (Reference; Probe [number]):
Alleles in kb/(Popul Freq) Const Bands (kb)
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[1] TaqI A-RFLP (Winqvist-1989; Probe [1]): A1= 8.0/(0.17); A2= 6.0/(0.83); CBs= no; [2] TaqI B-RFLP (Winqvist-1989; Probe [1]): B1= 3.3/(0.39); B2= 2.2/(0.61); CBs= no" |
|
REF |
CLO,COD,SEQ,PEP,EVO,LOC "Sharief FS &: BBRC, 160, N1, 79-86, 1989 LOC,CYG,MOL,PRO,POL "Winqvist R &: CCG, 51, (HGM10), 1108, 1989a LOC,CYG,MOL,PRO,POL "Winqvist R &: CCG, 52, 68-71, 1989b CLO,COD,SEQ,EXP "Yeh LC &: Gene, 60, 191-196, 1987 |
|
KEY |
sex, onc |
|
CLA |
coding, basic |
|
LOC |
03 q21.3-25.2 |
|
MIM |
MIM: 171790 |
|
EZN |
ENZYME: 3.1.3.2 |
