Gene: [04q21/IGJ] immunoglobulin, J linker protein for alpha/mu subunits; [JCH ]


FUN

This peptide links (with S-S bonds) the heavy subunits (alpha and mu) within the IgA dimer or IgM pentamer. It also modulates the convertion of membrane form of Ig into the secretory one. The locus should not to be confused with the J region between constant and variable areas of heavy and light subunits."

MOP

IGJ peptide contains 137 amino acid residues, sequence of them showing no homology with the multigene immunoglobulin family."

FAG

IGJ probes reveal, in EcoRI hydrolyzate of the genomic DNA, two independent fragments, 8 and 4.5 kb in length. Only the former contains the coding IGJ gene mapped in chromosome 4q. The other fragment seems to contain an IGJ-like sequence, which is probably located in chromosome 8 (see GEM:00.0/IGJL)."

REF

REV,IDN,FUN,STR "Koshland ME: Annu Rev Immunol, 3, 425-453, 1985
LOC,MOL,POL "Max EE &: PNAS, 83, N15, 5592-5596, 1986
CLO,SEQ,FAG "Max EE, Korsmeyer: J Exp Med, 161, 832-849, 1985
MOP,GEN,EVO "Zikan &: PNAS, 82, N17, 5905-5909, 1985

SWI

 SWISSPROT: P01591

KEY

imm

CLA

coding, basic

LOC

04 q21

MIM

 MIM: 147790

SYN

JCH