Gene: [04q35/KLK3] kallikrein 3, plasma (Fletcher factor); Fletcher factor deficiency (plasma kallikrein deficiency);
COM | The KLK3 gene was mapped to Chr 4q35 by in situ hybridization (Beaubien-1991). |
PAT | DeLa Cadena-1995 reported studies of a 9-year-old patient with markedly prolonged APTT but normal prothrombin time and bleeding time and also reviewed the role of prekallikrein in thrombosis." |
FUN | [1] Plasma
kallikrein is a serine protease that, among other roles, plays a part in
blood coagulation, fibrinolysis, and complement activation. These events
may be mediated through protein substrates (e.g. see GEM:03p/ITIH4) produced by partial proteolysis by
KLK3. [2] Plasma prekallikrein, also known as Fletcher factor (Mr 88,000), and factor XI (GEM:04q35/F11) are zymogens of 2 distinct serine proteinases present in normal plasma." |
FAG | See GEM:19q13/KLK1. |
REF | PAT,HIS "Aznar JA &: Scand J Haematol, 21, 94-98, 1978 GEN,SEQ,LOC "Beaubien G &: Biochemistry, 30, 1628-1635, 1991 PAT,FOG "Bouma BN &: J Clin Invest, 78, 170-176, 1986 PAT,REV,FUN "DeLa Cadena RA: Am J Hematol, 48, 273-277, 1995 CLO,EXP,LOC "Dunne J &: Genomics, 30, 207-223, 1995 |
SWI | SWISSPROT: P03952 |
KEY | pep, serp |
CLA | coding, basic |
LOC | 04 q35 |
MIM | MIM: 229000 |
EZN | ENZYME: 3.4.21.34 |
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