Gene: [04q/FAB2] fatty acid binding protein 2, intestinal; insulin resistance? (fat transport diturbance?); [FABP2 ]


COM

See GEM:02p11/FAB1.

FAG

See GEM:03q2/RBPC1.

GEN

[1] The gene length is 3.5 kb. Exons: 4 (103/128, 173, 108, and 312 bp); introns: 3 (1194, 1023, and 444 bp). The 3'-vicinity is flanked by an Alu-repeat (Sweetser-1987).
[2] The length of the mature transcript is 0.72 kb. The protein consists of 132 amino acids (MM 15.1 kD)."

ASS

[1] An association between insulin resistance and homozygosity or heterozygosity for the threonine-encoding allele among Pima Indians in Arizona was found (Baier-1995).
[2] Hegele et al. hypothesized that allelic variation in the amino acid sequence of the FABP2 could be related to variation in body mass index (BMI) and associated clinical phenotypes in aboriginal Canadians. Their findings suggest that the FABP2-T54 variant is associated with differences in fat metabolism in this aboriginal population (Hegele-1996)."

REF

MUT,ASS,PHE "Baier LJ &: J Clin Invest, 95, 1281-1287, 1995
MUT,ASS,PHE "Hegele RA &: J Clin Endocrinol Metab, 81, 4334-4337, 1996
LIN,ASS,PHE "Prochazka M &: Diabetes, 42, 514-519, 1993
LOC,FAG "Sparkes RS &: CCG, 46, (HGM9), 697, 1987
GEN,SEQ,EVO,FAG,EXP "Sweetser DA &: JBC, 262, 16060-16071, 1987

SWI

SWISSPROT: P12104

KEY

git, lip, trp

CLA

coding, basic

LOC

04 q28-31

MIM

MIM: 134640

SYN

FABP2