Gene: [05q34/DUSP1] dual specificity phosphatase 1 (EC:3.1.3.48 and EC:3.1.3.16); protein-tyrosine phosphatase, nonreceptor type, 10; MAP kinase phosphatase 1;


FUN

DUSP enzymes have dual specificity for tyrosine and threonine; the enzymes specifically inactivate mitogen-activated protein (MAP) kinase in vitro (Alessi-1993)."

REL

GEM:02q11/DUSP2; GEM:17q21/DUSP3; GEM:08p1/DUSP4; GEM:10q25/DUSP5; GEM:12q2/DUSP6; GEM:03p21/DUSP7; GEM:11p155/DUSP8; GEM:10q112/DUSP8P; GEM:0Xq28/DUSP9."

REF

EXP,FUN "Alessi DR &: Oncogene, 8, N7, 2015-2020, 1993
CLO,EXP "Chu Y &: JBC, 271, N11, 6497-6501, 1996
LOC "Emslie EA &: Hum Genet, 93, 513-516, 1994
CLO,SEQ "Keyse SM, Emslie EA: Nature, 359, 644-647, 1992
LOC "Martell KJ &: Genomics, 22, 462-464, 1994

SWI

SWISSPROT: P28562

CLA

coding, basic

LOC

05 q34

MIM

MIM: 600714

EZN

ENZYME: 3.1.3.48

鸯铗痂蝈 蜞赕:

  • Gene: [10^/PRKM8] protein kinase, mitogen-activated 8 (MAP kinase); stress-activated protein kinase 1; c-jun N-terminal kinase 1;