Gene: [06p2131/MLN] motilin (gastrointestinal hormone);
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GEN |
[1] The gene length: 9.3 kb; exons: 5; introns: 4 (2.7; 1.7; 3.5;
0.7 kb).
[2] The processed trancript (0.7 kb) contains 5'-unt (untranslated), 72-bp region and the following areas: the signal peptide (25 amino acid residues), the motilin itself (22 amino acid residues), the C-terminal peptide (83 amino acids), which function is currently unclear, and the 3'-unt region (155 bp). All these areas are coded by five exons, the motilin, in particular, being coded by the 3'-half of 2nd exon and by the 5'-half of 3d one. Its amino acid sequence is the following: FVPIFTYGELQRMQEKERNKGQ." |
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REF |
PRO,SEQ,EXP,EVO "Bond &: Mol Endocrinol, 2, 175-180, 1988 IDN,PEP,VER "Brown &: Gastroenterology, 62, 401-404, 1972 GEN,STR,MOP,EXP "Daikh DI &: DNA, 8, 615-621, 1989 LOC,CYG,MOL "Fan &: CCG, 51, (HGM10), 997, 1989 PEP,FUN "Itoh &: Scand J Gastroenterol, 11, (Suppl 39), 93-110, 1976 PEP,FUN "Rennie &: Gut, 20, A912, 1979 IDN,PEP,VER "Schubert, Brown: Can J Biochem, 52, 7-8, 1974 PRO,SEQ,EXP,EVO "Seino Y &: FEBS Lett, 223, 74-76, 1987 GEN,STR,MOP,EXP,LOC "Yano H &: FEBS Lett, 249, N2, 248-252, 1989 |
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KEY |
git, horm |
|
CLA |
coding, basic |
|
LOC |
06 p21.31 |
|
MIM |
MIM: 158270 |
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