Gene: [06p2133/HLADMA] major histocompatibility complex, class II, DM alpha; [HLA-DMA ]
|
FUN |
The HLA-DMA and HLA-DMB (GEM:06p2133/HLADMB) genes are required for the normal assembly of peptides with MHC class II molecules (FAM:MHC2/06p2133) and encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation (Morris-1994; Fling-1994)." |
|
EVO |
Sequence differences of HLA-DMA and HLA-DMB suggested that they originated before divergence of the main class II genes (Radley-1994)." |
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REF |
NOM "Bodmer JG &: Tissue Antigens, 39, 161-173, 1992 CLO,FUN,EXP "Ceman S &: J Immunol, 154, 2545-2556, 1995 FUN,EXP "Fling SP &: Nature, 368, 554-558, 1994 IDN,PRO,LIN,LOC,MAP "Kelly AP &: Nature, 353, 571-573, 1991 FUN,EXP "Morris P &: Nature, 368, 551-554, 1994 GEN,SEQ,EVO "Radley E &: JBC, 269, 18834-18838, 1994 |
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KEY |
imm, img |
|
CLA |
coding, basic |
|
LOC |
06 p21.33 |
|
MIM |
MIM: 142855 |
|
SYN |
HLA-DMA |
