Gene: [06p21/CCND3] cyclin D3 (G1/S-specific);
|
FUN |
Cyclin D genes play the roles as effectors of G1 transition and are differentially and redundantly expressed during the G1 phase of the cell cycle." |
|
MOP |
See GEM:11q133/CCND1. |
|
PAT |
See GEM:11q133/CCND1. The cyclin D3 gene might also be altered in human malignancies. An iso(6p)chromosome is a frequent anomaly in retinoblastoma (Squire-1985; Horsthemke-1989). On the possible pathogenetic mechanism, see (Buchkovich-1989; Chen-1989; DeCaprio-1989; Lin-1991)." |
|
PSG |
GEM:06p21/CCND3P. |
|
REF |
PAT "Buchkovich K &: Cell, 58, 1097-1105, 1989 PAT "Chen &: Cell, 58, 1193-1198, 1989 PAT "DeCaprio JA &: Cell, 58, 1085-1095, 1989 PAT "Horsthemke B &: Cancer Genet Cytogenet, 37, 95-102, 1989 PAT "Lin &: EMBO J, 10, 857-864, 1991 PAT "Squire J &: Hum Genet, 70, 291-301, 1985 FUN,MOP,EXP,EVO,EAG,PAT "see GEM:11q133/CCND1 |
|
KEY |
nucm, onc, repr |
|
CLA |
coding, basic |
|
LOC |
06 p21 |
|
MIM |
MIM: 123834 |
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