Gene: [06p21/CCND3] cyclin D3 (G1/S-specific);


FUN

Cyclin D genes play the roles as effectors of G1 transition and are differentially and redundantly expressed during the G1 phase of the cell cycle."

MOP

See GEM:11q133/CCND1.

PAT

See GEM:11q133/CCND1. The cyclin D3 gene might also be altered in human malignancies. An iso(6p)chromosome is a frequent anomaly in retinoblastoma (Squire-1985; Horsthemke-1989). On the possible pathogenetic mechanism, see (Buchkovich-1989; Chen-1989; DeCaprio-1989; Lin-1991)."

PSG

GEM:06p21/CCND3P.

REF

PAT "Buchkovich K &: Cell, 58, 1097-1105, 1989
PAT "Chen &: Cell, 58, 1193-1198, 1989
PAT "DeCaprio JA &: Cell, 58, 1085-1095, 1989
PAT "Horsthemke B &: Cancer Genet Cytogenet, 37, 95-102, 1989
PAT "Lin &: EMBO J, 10, 857-864, 1991
PAT "Squire J &: Hum Genet, 70, 291-301, 1985
FUN,MOP,EXP,EVO,EAG,PAT "see GEM:11q133/CCND1

KEY

nucm, onc, repr

CLA

coding, basic

LOC

06 p21

MIM

MIM: 123834

鸯铗痂蝈 蜞赕:

  • HUGEN-鲨觌桧
  • HUGEN-鲨觌桧 沭箫稃 D3