Gene: [06p21/CDC5L] cell division cycle 5-like (homologous to CDC5 of S.pombe); pombe cell division cycle-5-related protein; [PCDC5RP ]
|
FUN |
The Schizosaccharomyces pombe cdc5 gene is a cell division cycle gene that is essential for the progression of the G2 phase and entry into mitosis. All eukaryotes have cdc5-like genes (Hirayama-1996)." |
|
GEN |
The gene length: 50 kb (approximately); exons: 16 (Groenen-1998). |
|
EXP |
Northern blot analysis revealed ubiquitous expression of a 3.4-kb mRNA; the protein is normally localized to the nucleus (Bernstein-1997; Groenen-1998)." |
|
ABR |
The chromosome 6 breakpoint in a patient with bilateral multicystic renal dysplasia and massive hydronephrosis resides in intron 9 of the CDC5L gene (Groenen-1998) showed that the chromosome 19 gene involved in the translocation is GEM:19q131/USF2 (Groenen-1996)." |
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REF |
IDN,CLO "Bernstein HS, Coughlin SR: JBC, 272, N9, 5833-5837, 1997 ASS,PAT,ABR,LIN "Fryns JP &: Hum Genet, 91, 514-515, 1993 ABR,PAT "Groenen PMA &: Genomics, 49, 218-229, 1998 ABR,GEN,PAT "Groenen PMA &: Genomics, 38, N2, 141-148, 1996 IDN,EVO,EAG "Hirayama T, Shinozaki K: PNAS, 93, 13371-13376, 1996 |
|
KEY |
repr, pep |
|
CLA |
coding, basic |
|
LOC |
06 p21 |
|
MIM |
MIM: 602868 |
|
SYN |
PCDC5RP |
