Gene: [06q21/CCNC] cyclin C (G1/S-specific);


FUN

Cyclin C might activate p34 (or a related kinase).

MOP

Cyclin C do not contain 'mitotic destruction motif'. However this protein contain PEST sequences, which have been suggested to target proteins for rapid (and constitutive) degradation, near the carboxyl terminus (PEST-FIND score +13)."

EXP

Cyclin C mRNAs accumulate predominantly early in G1 phase cells.

EVO

[1] Cyclin C is approximately equally homologous to other human cyclins (37% similarity to cyclin A) and yeast Clns (43% similarity to Cln1) in the most conserved region (including most of the cyclin box).
[2] A homolog of cyclin C has been identified in Drosophila (Leopold-1991). Drosophila and human cyclin C are considerably more closelly related to each other (72% identical residues overall) than Drosophila and human cyclin A or cyclin B, which are only 50%-55% identical even within the most conserved cyclin box domain. This degree of conservation across such an evolutionary distance suggests that there are strong constraints on cyclin C structure."

REF

IDN,FUN,MOP,EXP "Arion &: Cell, 55, 371-378, 1988
IDN,FUN,MOP,EXP "Booher, Beach: EMBO J, 6, 3441-3447, 1987
IDN,FUN,MOP,EXP "Draetta &: Cell, 56, 829-838, 1989
IDN,FUN,MOP,EXP "Dunphy &: Cell, 54, 423-431, 1988
IDN,FUN,MOP,EXP "Fang, Newport: Cell, 66, 731-742, 1991
IDN,FUN,MOP,EXP "Galaktionov KI, Beach: Cell, 67, 1181-1194, 1991
IDN,FUN,MOP,EXP "Gautier &: Cell, 54, 433-439, 1988
IDN,FUN,MOP,EXP "Giordano &: Cell, 58, 981-990, 1989
IDN,FUN,MOP,EXP "Goebl, Byers: Cell, 54, 739-740, 1988
IDN,FUN,MOP,EXP "Gould, Nurse: Nature, 342, 39-45, 1989
IDN,FUN,MOP,EXP "Inaba T &: Genomics, 13, 565-574, 1992
IDN,FUN,MOP,EXP "Koff A &: Cell, 66, 1217-1228, 1991
IDN,FUN,MOP,EXP "Labbe &: Cell, 57, 253-263, 1989a
IDN,FUN,MOP,EXP "Labbe &: EMBO J, 8, 3053-3058, 1989b
IDN,FUN,MOP,EXP "Meijer &: EMBO J, 8, 2275-2282, 1989
IDN,FUN,MOP,EXP "Pines J, Hunter: J Cell Biol, 115, 1-17, 1991
IDN,FUN,MOP,EXP "Pines J, Hunter: Nature, 346, 760-763, 1990
PRO,COD,SEQ "Pines J, Hunter: Cell, 58, 833-846, 1989
IDN,FUN,MOP,EXP "Solomon &: Cell, 54, 738-739, 1988
IDN,FUN,MOP,EXP "Tsai LH &: Nature, 353, 174-177, 1991
EVO,EAG "Xiong Y &: Genomics, 13, 575-584, 1992
IDN,FUN,MOP,EXP "Xiong Y &: Cell, 65, 691-699, 1991
EVO,EAG "Xiong Y, Erickbush : EMBO J, 9, 3353-3362, 1990
EVO,EAG "Yoshida MC &: PNAS, 85, 4861-4864, 1988

SWI

SWISSPROT: P24863

KEY

nucm, onc, repr

CLA

coding, basic

LOC

06 q21

MIM

MIM: 123838

鸯铗痂蝈 蜞赕:

  • Gene family: cyclins; (CCNA CCNB1 CCNB2 CCNC CCND1 CCND2 CCND2P CCND3 CCND3P CCNE CCNF CCNG1 CCNG2 CCNH CCNL1 CCNT1 CCNT2)