Gene: [07p13/GCK] glucokinase (hexokinase 4, maturity onset diabetes of the young 2); hexokinase 4 (liver and pancreatic) (glucokinase); maturity onset diabetes of the young 2 (MIM:125851);


FUN

Systematic name: ATP:D-hexose 6-phosphotransferase. Catalyzes reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. ITP and dATP can act as donors."

FAG

About hexokinases see GEM:10q22/HK1.

EXP

Liver isozyme (SwissProt: HXKH Q05810) and pancreatic isozyme (SwissProt: HXKP P35557) are produced by alternative splicing."

REL

GEM:02p223/GCKR.

REF

SEQ "Koranyi LI &: Diabetes, 41, 807-811, 1992
LOC,LIN "Matsutani A &: Genomics, 12, 319-325, 1992
LOC,LIN "Mishra SK &: Genomics, 12, 326-334, 1992
COD,POL,LOC "Nishi S &: Diabetologia, 35, 743-747, 1992
SEQ "Tanizawa Y &: Mol Endocrinol, 6, 1070-1081, 1992

SWI

SWISSPROT: Q05810; HXKP P35557

KEY

carb, mtbd

CLA

coding, basic

LOC

07 p13

MIM

MIM: 138079

EZN

ENZYME: 2.7.1.1

鸯铗痂蝈 蜞赕:

  • Gene: [20q1/HNF4A] hepatocyte nuclear factor 4, alpha; transcription factor 14, hepatic; maturity onset diabetes of the young 1 (MIM:125850); [TCF14 MODY1 ]
  • Gene: [02q36/IRS1] insulin receptor substrate 1; noninsulin-dependent diabetes mellitus (NIDDM, MIM:125853); [HIRS-1 ]
  • 缅睇 沐犟铌桧噻
  • 枢痱 徨腙 汶铌桧噻