Gene: [07p22/CMKRL2] chemokine receptor-like 2 (heptahelix); G protein-coupled receptor 30; IL8-related receptor DRY12; [GPR30 DRY12 ]
COM | [1]
Owman-1996 performed PCR of template DNA from human B-cell lymphoblasts
using degenerate primers to G protein-coupled receptors. They identified a
full-length cDNA encoding a 375-amino acid protein, which they termed
CMKRL2. CMKRL2 maps to Chr 7p22 by fluorescence in situ hybridization.
[2] Based upon PCR analysis in somatic hybrid cell lines the GPR30 gene was mapped to Chr 7p22 (Carmeci-1997). The pattern of expression of the gene indicated that the receptor may be involved in physiologic responses specific to hormonally responsive tissues." |
TIS | The CMKRL2 is expressed in the Burkitt lymphoma cell lines Raji and Daudi but not in T-cell lymphoma Jurkat cells, T- or B-cell leukemias, chronic myelogenous leukemia, or other cancer cell lines; northern blot analysis of normal tissue showed widespread expression in many tissues including the brain; there was no detectable mRNA in placenta, bone marrow, or peripheral blood leukocytes (Owman-1996)." |
REF | CLO,LOC "Carmeci C &:
Genomics, 45, N3, 607-617, 1997 CLO,SEQ "Feng Y, Gregor P: BBRC, 231, 651-654, 1997 CLO,SEQ "Kvingedal AM, Smeland EB: FEBS Lett, 407, 59-62, 1997 CLO,SEQ,TIS,LOC "O'Dowd BF &: Genomics, 47, N2, 310-313, 1998 COD,LOC,EXP "Owman C &: BBRC, 228, N2, 285-292, 1996 CLO,SEQ "Takada Y &: BBRC, 240, 737-741, 1997 |
SWI | SWISSPROT: Q99527 |
KEY | mem, recp |
CLA | coding, basic |
LOC | 07 p22 |
MIM | MIM: 601805 |
SYN | GPR30 DRY12 |
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