Gene: [07q2/GNAI1] guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; adenylate cyclase inhibitor GI, alpha-I1;

GEN	The gene consists of three exons and four introns. The human mRNAs are 2.2 and 3.9 kb in length. Five GC blocks were found that are located 118, 182, 354, 364, and 533 bp upstream the start and a TGTTCT block, 784 bp upstream the start, were found. Typical TATA-like sequences and CCAAT blocks are lacking."
EVO	The human alpha-I1 protein is almost identical to the bovine alpha-I peptide with respect to amino acid sequence. The coding region of human gene is highly homologous to cDNA of bovine alpha-GI; their 5'-flanking regions also share homology. The values of homology for flanking regions (positions 1-115) is 71%, and for coding regions (exons 1-3), 96-100%."
REF	GEN,LOC,EAG "Bloch DB &: AJHG, 42, 884-888, 1988 CLO,SEQ,EVO "Bray P &: PNAS, 84, N15, 5115-5119, 1987 GEN,FAG,EAG "Itoh H &: JBC, 263, N14, 6656-6664, 1988 HUM,FUN,EXP,FAG "Kim SY &: PNAS, 85, N12, 4153-4157, 1988 PRO,LOC,FAG "Neer EJ &: Hum Genet, 77, 259-262, 1987
SWI	SWISSPROT: P04898
KEY	neu, nucm, onc
CLA	coding, basic
LOC	07 q21-22
MIM	MIM: 139310