Gene: [07q2/MTERF] transcription termination factor, mitochondrial;
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FUN |
The mitochondrial transcription termination factor plays a central role in attenuating transcription between the 16S ribosomal RNA (GEM:0Mh1671/MTRNR2) and the tRNA-leu (GEM:0Mh3230/MTTL1) genes in the heavy strand of mitochondrial DNA, and therefore is a part of the regulatory system that allows high levels of ribosomal RNA expression relative to downstream genes (Daga-1993). The MTER-Factor was identified as a DNA binding protein that protected a 28 bp region immediately adjacent and downstream of the 3' ends of the mitochondrial DNA constructs containing the main heavy strand promoter and the transcription termination site at the 16S rRNA/leucyl-tRNA boundary (in vivo and in vitro) (Kruse-1989)." |
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FAG |
Another gene coding for transcription termination factor (non-mitochondrial) should be in human genome: GEM:00.0/TTF1." |
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REF |
EXP,MEB,MOP "Daga A &: JBC, 268, 8123-8130, 1993 COD,SEQ,LOC "Fernandez-Silva P &: EMBO J, 16, 1066-1079, 1997 MEB,FUN "Kruse B &: Cell, 58, N2, 391-397, 1989 |
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KEY |
trc, mito |
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CLA |
coding, basic |
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LOC |
07 q21-22 |
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MIM |
MIM: 602318 |
