Gene: [07q311/ST7] suppression of tumorigenicity 7 (breast?; ovarian?); ovarian carcinoma?; [TSG7 ]
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COM |
A distinct tumor suppressor gene involved in primary ovarian carcinomas was suggested by the finding of Zenklusen et al. of allelic loss at 7q31.1 in such carcinomas. In 17 of 19 informative cases (73%), loss of heterozygosity (LOH) was detected in D7S522 at 7q31.1 (Zenklusen-1995a,b)." |
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REF |
CLO,SEQ "Ogata T &: Mol Cell Biol, 13, 6036-6043, 1993 REV,FAG,EXP "Zenklusen JC &: Mol Carcinog, 15, 167-175, 1996 LOC "Zenklusen JC &: Cancer Res, 55, 1347-1350, 1995a LOC "Zenklusen JC &: Oncogene, 11, N2, 359-363, 1995b CLO,SEQ,STR "Zenklusen JC &: PNAS, 91, 12155-12158, 1994 |
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KEY |
onc |
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CLA |
coding, basic |
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LOC |
07 q31.1 |
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MIM |
MIM: 600833 |
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SYN |
TSG7 |
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