Gene: [07q32/CPA1] carboxypeptidase A1 (pancreatic);


COM

Before 1975 the code was EC:3.4.2.1; since 1975, EC:3.4.12.2; since 1984, EC:3.4.17.1. HGM and GDB indicate the old code, EC:3.4.2.1."

FUN

[1] Carboxypeptidase A1 is a pancreatic enzyme that splits C-terminal L-amino acids, except for Arg, Lys, Pro.
[2] Systematic name: peptidyl-L-amino acid hydrolase. Catalyzes reaction: peptidyl-L-amino acid + H(2)O = peptide + L-amino acid."

FAG

The MIM Catalogue includes two other carboxypeptidases: M (MIM:114860) and N (MIM:212070). The gene for the former have already been cloned (Tan-1989) and mapped (GEM:12q15/CPM); the latter have been identified both biochemically and by its deficiency, which is inherited as an autosomal recessive marker (see GEM:13q1411/CPB2)."

REL

GEM:00.0/CPA2; GEM:03q2/CPA3; GEM:00.0/CPB1; GEM:13q1411/CPB2; GEM:00.0/CPD; GEM:04^/CPE; GEM:12q15/CPM; GEM:00.0/CPN2; GEM:17q23/DCP1."

REF

PRO,LOC,EVO,COM "Honey NK &: Hum Genet, 72, 27-31, 1986
PRO,LOC,EVO,COM "Honey NK &: CCG, 37, (HGM7), 492, 1984
PRO,COD,SEQ,EVO,FAG "Tan F &: JBC, 264, 13165-13170, 1989

SWI

 SWISSPROT: P15085

KEY

git, pep

CLA

coding, basic

LOC

07 q32

MIM

 MIM: 114850

EZN

 ENZYME: 3.4.17.1