Gene: [07q35/PRSS1] protease, serine, 1 (trypsin 1); trypsin 1; trypsinogen deficiency; pancreatitis, hereditary (calcific; MIM:167800);

COM	Rowen-1996 narrowed the assignment somewhat to Chr 7q35.
FUN	Systematic name is not yet assigned. Trypsin catalyzes hydrolysis of peptide bonds. The preferential cleavage: Arg-|-Xaa, or Lys-|-Xaa."
REL	GEM:07q35/PRSS2; GEM:00.0/PRSS3; GEM:00.0/PRSS4; GEM:03q2/PRSS5; GEM:00.0/PRSS6; GEM:21q21/PRSS7; GEM:16p112/PRSS8; GEM:19q133/PRSS9; GEM:10q2/PRSS11, GEM:19q133/PRSSL1. See also GEM:02p12/PAP."
REF	PRO,SEQ,FAG,EXP "Craik CS &: JBC, 259, 14255-14264, 1984 PRO,SEQ,FAG,EXP "Emi M &: Gene, 41, 305-310, 1986 PRO,LOC,CYG,FAG,EVO "Honey NK &: CCG, 37, (HGM7), 492, 1984a PRO,LOC,CYG,FAG,EVO "Honey NK &: Somat Cell Mol Genet, 10, 369-376, 1984b PRO,SEQ,FAG,EXP "Kimland M &: Clin Chim Acta, 184, 31-46, 1989 PAT,LOC,LIN "Le Bodic L &: Hum Mol Genet, 5, 549-554, 1996 PRO,LOC,CYG,FAG,EVO "Naylor SL &: CCG, 46, 669, 1987 PAT,LOC,LIN "Pandya A &: Genomics, 38, N2, 227-230, 1996 GEN,SEQ,LOC,FAG "Rowen L &: Science, 272, 1755-1762, 1996 PAT "Townes PL &: J Pediatr, 71, 220-224, 1967 PAT "Townes PL: J Pediatr, 66, 275-285, 1965 PAT,LOC,LIN "Whitcomb DC &: Gastroenterology, 110, 1975-1980, 1996a PAT,MUT "Whitcomb DC &: Nature Genet, 14, 141-145, 1996b
SWI	SWISSPROT: P07477
KEY	git, pep
CLA	coding, basic
LOC	07 q35
MIM	MIM: 276000
EZN	ENZYME: 3.4.21.4