Gene: [07q36/PTPRN2] protein tyrosine phosphatase, receptor type, N polypeptide 2; protein tyrosine phosphatase, receptor type, N-beta; islet cell antigen-related protein tyrosine phosphatase; phogrin;

COM	Cui-1996 used degenerate PCR to screen for protein tyrosine phosphatases (PTPs) in a human colon carcinoma cell cDNA library and isolated a novel gene of the receptor-type PTP family (FAM:PTP/00.0). They analyzed the sequence and found that this cDNA, termed IAR (for islet antigen-related), encoded a protein of 1,015 amino acids which was 43% identical to IA-2 (GEM:02q3/PTPRN), an autoantigen associated with insulin-dependent diabetes mellitus (IDDM)."
FUN	[1] Systematic name: protein-tyrosine-phosphate phosphohydrolase. [2] Reaction catalyzed: protein tyrosine phosphate + H(2)O = protein tyrosine + orthophosphate."
FAG	This gene is homologous to another receptor-type PTP, IA-2 (GEM:02q3/PTPRN).
REL	See GEM:20p13/PTPRA.
REF	COD,EXP,FUN "Cui L &: JBC, 271, 24817-24823, 1996 COD,EXP,FUN "Kawasaki E &: BBRC, 227, 440-447, 1996 MAP,FAG "Morahan G &: Mammal Genome, 9, 593-594, 1998 CLO,SEQ "Nagase T &: DNA Res, 4, N2, 141-150, 1997 CLO,SEQ "Smith PD &: BBRC, 229, N2, 402-411, 1996 COD,SEQ,EXP "Wasmeier C, Hutton JC: JBC, 271, 18161-18170, 1996
SWI	SWISSPROT: Q92932
KEY	pep, recp
CLA	coding, basic
LOC	07 q36
MIM	MIM: 601698
EZN	ENZYME: 3.1.3.48