Gene: [08q13/CRH] corticotropin releasing hormone; [CRF ]
GEN | The gene length is 2.6 kb. The gene contains one intron, 800 bp in length. |
FUN | Corticotropin releasing hormone stimulates the ACTH secretion by the adenohypophysis; the main function is the participation in the response to stress. This hormone is also synthesized by placenta, the peak level being reached by the 40th week of pregnancy." |
MOP | The active peptide consists of 41 amino acid residues (the preprohormone comprises 191 amino acids)." |
TIS | The protein is secreted by the cells of hypothalamic paraventricular nucleus." |
FAG | A gene for another hypothalamic factor, gonadotrophin releasing hormone, is also located in Chr 8, but in the short arm (GEM:08p/GNRH1)." |
REF | LOC "Arbiser &: CCG, 47, 113-116, 1988 SEQ "Shibahara S &: EMBO J, 2, 775-779, 1983 |
SWI | SWISSPROT: P06850 |
KEY | neu, horm |
CLA | coding, basic |
LOC | 08 q13 |
MIM | MIM: 122560 |
SYN | CRF |
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