Gene: [08q13/CRH] corticotropin releasing hormone; [CRF ]


GEN

The gene length is 2.6 kb. The gene contains one intron, 800 bp in length.

FUN

Corticotropin releasing hormone stimulates the ACTH secretion by the adenohypophysis; the main function is the participation in the response to stress. This hormone is also synthesized by placenta, the peak level being reached by the 40th week of pregnancy."

MOP

The active peptide consists of 41 amino acid residues (the preprohormone comprises 191 amino acids)."

TIS

The protein is secreted by the cells of hypothalamic paraventricular nucleus."

FAG

A gene for another hypothalamic factor, gonadotrophin releasing hormone, is also located in Chr 8, but in the short arm (GEM:08p/GNRH1)."

REF

LOC "Arbiser &: CCG, 47, 113-116, 1988
SEQ "Shibahara S &: EMBO J, 2, 775-779, 1983

SWI

SWISSPROT: P06850

KEY

neu, horm

CLA

coding, basic

LOC

08 q13

MIM

MIM: 122560

SYN

CRF

鸯铗痂蝈 蜞赕:

  • 饰幸仁我形先-论崖瘟纹睦拶壬 岳室涡 (饰幸仁嗡攘判韧, CRF)
  • CRH 沐 觐痱桕铍栳屦桧