Gene: [08q22/POP1] POP1 (processing of precursor RNAs) homolog;
|
COM |
[1] The POP1 gene was mapped to chromosome 08q22 by FISH
(Schmiedeknecht-1997).
[2] The POP1 and PCSP (GEM:08q22/PCSP) genes are oriented head-to-head, separated by a 102-bp region that contains a bidirectional promoter (Schmiedeknecht-1997)." |
|
FUN |
In yeast, POP1 gene encodes a protein component of both RNase P (cleaving precursor tRNA molecules) and RNase MRP (cleaving 5.8S ribosomal RNA) (Lygerou-1994). In human, POP1 was proven to associate with both RNase P and RNase MRP snRNAs, and with RNase P enzymatic activity (Lygerou-1996)." |
|
MOP |
Human POP1 encodes a predicted 1,024-amino acid protein that has a pI of 9.86. On Northern blots, human POP1 is expressed as a major 4.1-kb and minor 6-kb transcript, perhaps due to alternative polyadenylation signals. Anti-POP1 antibodies recognize a doublet of approximately 115 kd on Western blots. In HeLa cells, human POP1 localizes to the nucleus and strongly accumulates in the nucleolus." |
|
REF |
COD,SEQ,EVO,EXP "Lygerou Z &: EMBO J, 15, 5936-5948, 1996 INV,FUN,MEB "Lygerou Z &: Genes Dev, 8, 1423-1433, 1994 LOC,LIN,MAF "Schmiedeknecht G &: BBRC, 241, 59-67, 1997 |
|
KEY |
trc, nucm |
|
CLA |
coding, basic |
|
LOC |
08 q22 |
|
MIM |
MIM: 602486 |
