Gene: [08q23/COL14A1] undulin (fibronectin-tenascin-related); collagen, type XIV, alpha 1; [UND ]


COM

[1] The COL14A1/UND gene was mapped to 8q23 by FISH (Schnittger-1995).
[2] Undulin is a noncollagenous extracellular matrix protein (Schuppan-1990). The undulin is identical to collagen XIV (Bauer-1997)."

FUN

Undulin is a large glycoprotein of the interstitial extracellular matrix. It is restricted to dense and soft connective tissues and is associated with mature collagen fibrils (Schuppan-1990)."

MOP

[1] The predicted 1,780-amino acid undulin protein contains a putative signal peptide followed immediately by a fibronectin type III domain (GEM:02q34/FN1); a VWF A domain (GEM:12p13/F8VWF); 7 fibronectin type III domains; a second VWF A domain; and several collagenous and noncollagenous domains in the C-terminal region (Just-1991; Bauer-1997).
[2] A homotrimeric collagen XIV molecule was extracted from fetal bovine skin and tendon. It has a triple helical disulfide-bonded domain homologous to type IX and type XII collagens (Dublet-1991; see also FAM:COLL/00.0)."

REL

On tenascin gene see GEM:09q33/HXB.

REF

COD,SEQ,EVO "Bauer M &: BBA, 1354, N3, 183-188, 1997
MAM,PRO,SEQ,MOP,EVO "Dublet B, van der Rest M: JBC, 266, 6853-6858, 1991
COD,SEQ "Just M &: JBC, 266, 17326-17332, 1991
LOC "Schnittger S &: CCG, 68, 233-234, 1995
EXP,MEB "Schuppan D &: JBC, 265, N15, 8823-8832, 1990

KEY

exce

CLA

coding, basic

LOC

08 q23

MIM

MIM: 120324

SYN

UND

鸯铗痂蝈 蜞赕:

  • Gene superfamily: collagen proteins; (@COL1 COL2A1 COL3A1 @COL4 @COL5 @COL6 COL7A1 @COL8 @COL9 COL10A1 @COL11 COL12A1 COL12A1L COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1)