Gene: [08q243/GPT] glutamic-pyruvate transaminase; alanine aminotransferase 1, soluble;


POL

The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 (erythrocyte form) and an asparagine in GPT-2 (hepatic form), which causes a gain or loss of an NlaIII restriction site (Sohocki-1997)."

FUN

Systematic name: L-alanine:2-oxoglutarate aminotransferase. The reaction catalyzed: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate."

REF

PEP,SEQ "Doyle JM &: Biochem J, 270, N3, 651-657, 1990
LOC,CYG "Jeremiah &: CCG, 37, (HGM7), 498, 1984
LIN,MAG "O'Connell &: CCG, 46, (HGM9), 673, 1987
LOC,CYG "Rocha J &: Hum Genet, 80, 299-300, 1988
CLO,SEQ,LOC,POL "Sohocki MM &: Genomics, 40, N2, 247-252, 1997

SWI

SWISSPROT: P24298

KEY

hem, ant, aac

CLA

coding, basic

LOC

08 q24.3

MIM

MIM: 138200

EZN

ENZYME: 2.6.1.2

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