Gene: [09q223/XPA2] xeroderma pigmentosum, complementation group A2; fast complementation DNA repair in xeroderma (group A2); [XPA XP1 XPAC ]

COM	MIM, with reference to the data of Takebe-1989 (personal communication) on the cloning of this gene and results of in situ hybridization on chromosome, indicates its regional location as 9q22, while Henning-1989, basing on results of blot hybridization with somatic hybrid DNA, reported the localization to 9q34. Possibly different forms and genes of xeroderma pigmentosum are dealt with."
MOP	Fast kinetic is characteristic for the complementation.
HET	This form of xerodeerma pigmentosum was previously (Keijzer-1984,1987) mapped to Chr 1 (GEM:01q4/XPA1). However, in 1989 (see Comment) it was demonstrated that a similar (with respect to clinical genetic features) mutation is related to a gene in Chr 9q. This suggests a genetic heterogeneity in complementation group A of reparation mutations; more than ten forms of xeroderma pigmentosum are currently known; for more details, see GEM:01q4/XPA1."
REF	REV,MOP,EXP,LOC "Cleaver JE: Carcinogenesis, 11, 875-882, 1990 LIN,PAT "El-Hefnawi &: Ann Hum Genet, 28, 273-290, 1965 LOC,CYG "Henning &: J Cell Biochem Suppl, 13, (D), 53, 1989 LOC,CYG "Kaur GP, Athwal: PNAS, 86, N22, 8872-8876, 1989 COM,LOC,CYG,MEB "Keijzer W &: Exp Cell Res, 169, 490-501, 1987 COM,LOC,CYG,MEB "Keijzer W &: CCG, 37, (HGM7), 508, 1984 PHE "Keijzer W &: Exp Cell Res, 140, 119-125, 1982 REV,PAT,PHE "Kraemer &: Arch Derm, 123, 241-250, 1987
SWI	SWISSPROT: P23025
KEY	derm, neu, repr
CLA	coding, basic
LOC	09 q22.3
MIM	MIM: 278700
SYN	XPA XP1 XPAC