Gene: [10q112/ALOX5] arachidonate 5-lipoxygenase (leukotrien A4 synthase); arachidonate 5-lipoxygenase, variable expression of;


GEN

The gene length is 82 kb. Exons: 14; they are 82-613 bp in length.

MOP

The size of the mature transcript is 2.7 kb. The protein have MM 77839D
(673 amino acids)."

FUN

The enzyme catalyzes the first two steps of the synthesis of peptidoleukotriens and a hemotaxis factor, leukotrien B4, which play an important role in inflammatory and allergic responses. The cytoplasmic enzyme, which acts in the presence of ATP and calcium ions, was isolated from leukocytes and red blood cells, as well as from lung and placenta tissues."

REL

GEM:00.0/ALOX5AP; GEM:17p131/ALOX12; GEM:17^/ALOX12P1; GEM:00.0/ALOX12P2; GEM:17^/ALOX15."

REF

PRO,SEQ,MOP "Dixon RAF &: PNAS, 85, N2, 416-420, 1988
REV,FUN "Ford-Hutchinson, Letts: Hypertension, 8, (Ii.), 44-49, 1986
LOC "Funk CD &: PNAS, 89, 3962-3966, 1992
GEN,SEQ,MOP "Funk CD &: PNAS, 86, 2587-2591, 1989
MUT "In KH &: J Clin Invest, 99, N5, 1130-1137, 1997
PRO,SEQ,MOP "Matsumoto T &: PNAS, 85, N1, 26-30, 1988
REV,FUN "Shimizu &: Int J Biochem, 20, N7, 661-666, 1988
LOC "Tunnacliffe A &: Hum Genet, 93, 313-318, 1994

SWI

SWISSPROT: P09917

KEY

hem, card, imm, mfd, lip

CLA

coding, basic

LOC

10 q11.2

MIM

MIM: 152390

EZN

ENZYME: 1.13.11.34

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